Migraine

A study finds CGRP monoclonal antibodies are not clinically superior to topiramate or Botox in treating chronic migraines, raising cost-effectiveness concerns.

Comorbid migraine and insomnia are linked to altered locus coeruleus connectivity, suggesting it is a biomarker for sleep disturbances and a potential therapeutic target.

A meta-analysis shows that wet cupping reduces migraine intensity but doesn't improve quality of life. Adjunctive therapies offer limited additional benefits.

A study of > 14,000 patients offers insights on real-world usage and characteristics of new rimegepant users, showing distinct patterns in acute vs. preventive treatment.

Triptans, including eletriptan and sumatriptan, offer better migraine relief than newer, more expensive drugs, suggesting they should be first-line treatments.

A study revealed erenumab at 140 mg is effective and safe in achieving remission of headaches caused by non-opioid medication overuse.

Taking ubrogepant at the first signs of a migraine, before headache onset, significantly reduces migraine symptoms and improves daily function, a study in Neurology reveals.

Investigators found patients with comorbid temporomandibular disorder, migraines, and fibromyalgia experienced longer pain duration than patients with only 1 comorbidity.

New research found high diastolic blood pressure is linked to greater odds of a female having a migraine. The study found no other associations between migraines and other CVD factors.

Data from a phase 2 randomized clinical trial demonstrate use of the GLP-1 receptor agonist exenatide could be used as a treatment for idiopathic intracranial hypertension in women.

Forget what you think you know about red wine or chocolate ‘activating’ migraine. Many commonly accepted “triggers” aren’t triggers at all.

Trigger avoidance-only strategies don’t actually help migraine patients improve. These are the proactive behaviors that do.

It’s time to stop just recommending trigger avoidance strategies to patients. These are the proactive behaviors that will actually help improve migraine.

There was no association found between migraines and Crohn’s disease or ulcerative colitis.

AXS-07 showed statistical significance for migraine pain freedom at 90 minutes, and at every time point after.

The oral CGRP antagonist becomes the first in its class approved for the indication.

The oral therapy showed benefit in reducing symptoms and migraine-related pain, as well as aura, within 2 hours of administration.

Drinking more than 3 servings of caffeinated beverages per day was associated with an increase in migraine headaches.

Rimegepant (rimegepant Zydis), which is a novel therapy for treatment of acute migraines, was found to reduce bothersome suymptoms and eliminate pain in a phase 3 clinical trial.

The approval is based on the findings of a 106-adult patient trial which assessed mean weekly headache episodes.

Overconfidence, anchoring errors, biases, and other factors have all led to misdiagnoses at points in my internal medicine career.

The Complete Response Letter highlights issues in the Chemistry, Manufacturing, and Controls section of the application.

While the diseases appear to be unrelated, there may be underlying factors that link them together.

An FDA decision on the application is expected by December 27, 2019.

If approved by the FDA later this year, the Allergan drug would become the first oral CGRP receptor antagonist approved for acute migraine treatment.

Galcanezumab was previously given a Breakthrough Therapy Designation for this indication.

Investigators suggest the findings mean anticoagulants or antiplatelets could potentially treat migraine patients with aura.

The FDA has approved sumatriptan nasal spray (TOSYMRA, previously known as DFN-02) for the acute treatment of migraine with or without aura in adults.

The non-invasive device is now the first and only FDA product approved for the prevention of cluster headache.

The FDA has approved Dextenza, a dexamethasone ophthalmic insert, for the treatment of ocular pain following ophthalmic surgery.