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Making History: The Epilepsy Phenome/Genome ProjectThis groundbreaking study aims to create a national resource to guide neurologists in selecting medications that are more effective and cause fewer, if any, side effects than currently available options.
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Lung Cancer Screening & Treatment: What Comes Next?The pulmonology and oncology expert panel returns for another discussion on lung cancer treatment challenges presented by the pandemic—and how the field can recover.
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FDA Grants Fast Track Designation to A4250 for Progressive Familial Intrahepatic CholestasisHere’s a round-up of recent designations granted by the FDA to products developed to treat rare diseases.
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A Dose of Truth about the Consequences of OpiophobiaThe treatment of intractable pain remains an unresolved controversy in American medicine. Although, in theory, it is generally accepted that pain must be adequately treated, particularly in cancer patients, the treatment of pain unrelated to malignancy remains a stubborn and highly contentious issue.
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Effectiveness and Cost-Effectiveness of Diabetes Prevention among Adherent ParticipantsOver 10 years, lifestyle intervention and metformin were cost-effective or cost saving compared with placebo.
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Low cholesterol level in midlife and quality of life in old ageWe found that lower cholesterol levels in middle age predicted lower total mortality and better physical quality of life in old age after 39 years of follow-up. No difference was seen in the mental component of quality of life. These findings support current guidelines for cholesterol goals and show that a low risk-factor level in midlife can affect long-term mortality and morbidity, postpone physical disability, and improve quality of life in old age.
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Health Care Reform: Guidance on Claims and Appeals RulesInterim final rules clarify the scope of internal claims and appeals procedures and external review processes under PPACA.
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How A Team-Based Approach Works For Treatment of Brain TumorsManmeet Ahluwalia, MD, Head of Operations in the Brain Tumor Center at Cleveland Clinic, explains what a team approach should look like when treating brain tumors and other rare cancers.
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Anomalous coronary circulation detected by coronary artery scanningAn asymptomatic 66-year-old man with a history of nonobstructing carotid artery plaque and sleep apnea was referred for cardiac computed tomography (CT) scanning for risk stratification. He exercised on a regular basis with no symptoms and had normal results on at least 2 nuclear stress tests, the last test being performed only 12 months earlier.
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Serial biomarker measurements in chronic heart failureCardiac troponin T (cTnT) and B-type natriuretic peptide (BNP) have been used to estimate prognosis in heart failure. However, most studies have evaluated decompensated patients using single measurements. To determine the value of serial measurements, we evaluated 190 stable chronic heart failure patients every 3 months during 2 years.
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Benefit of aspirin plus moderate-intensity oral anticoagulation compared with aspirin alone after acute coronary syndromesThe role of combination therapy with an oral anticoagulant and aspirin for patients recovering from an acute coronary syndrome is still being debated. The results of our meta-analysis showed that treatment with aspirin plus warfarin at international normalized ratio values between 2 and 3 significantly reduces the risk of major adverse events compared with aspirin alone but also increases the risk of major bleeding. For every 100 patients receiving combination therapy, approximately 3 major adverse events are prevented and 1 major hemorrhage occurs.
