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New Framingham Heart Study global cardiovascular risk instruments for use in primary prevention of atherosclerotic eventsCardiovascular risk factors vary somewhat for each specific atherosclerotic cardiovascular disease event; however, there is sufficient commonality to enable crafting of a global CVD risk-assessment instrument that accurately predicts total CVD risk and the risk of its individual components.
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Cardiovascular events in hypertension trials: A focus on perindoprilPharmacologic inhibition of the renin-angiotensin aldosterone system (RAAS) has become a widely accepted approach to lowering blood pressure (BP).
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Where's the Love for Tablet PCs in Psychiatry?Our most modern iteration of the portable, wirelessly connected, handwriting- and speech-recognition-capable computer is the "tablet PC."
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Non–ST-segment elevation ACS: Should all patients undergo cardiac catheterization?We performed a systematic review and meta-analysis of all clinical trials comparing routine invasive strategy with selective invasive strategy in patients with non–ST-segment elevation acute coronary syndrome. We did not find either strategy to offer an advantage over the other, even when we excluded trials that did not use coronary stents and glycoprotein IIb/IIIa inhibitors.
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The Importance of Rare Disease Awareness Among PhysiciansJames J. Maciejko, MS, PhD, FACC, stresses the importance of rare disease awareness among physicians for proper diagnosis and treatment.
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Community-acquired MRSA pericarditisOnly 2 cases of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) pericarditis have been reported in the English literature. Over the last 15 years, CA-MRSA has emerged as an increasingly common pathogen that is genetically and epidemiologically different from hospital-acquired MRSA (HA-MRSA).
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Can Tamoxifen Prevent Breast Cancer?The IBIS-I randomized control trial included women of ages 35-70 from 37 health centers in eight countries from April, 1992, until March, 2001 that were deemed to be at increased risk of developing breast cancer (by virtue of family history of breast cancer or abnormal benign breast disease), and randomized to treatment with oral tamoxifen or placebo for 5 years.
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Prognostic importance of elevated N-terminal-pro-BNP in patients with diabetes and acute myocardial infarctionDiabetes is a potent risk factor for adverse outcomes following acute myocardial infarction,1 but the mechanisms responsible for this association are not well understood.
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Use of Social Media by Health Care ProfessionalsSometimes the line between personal and professional gets blurred.
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Early statin therapy in acute coronary syndromePatients who survive an acute coronary syndrome are at much higher risk of a recurrent event within the following month than patients with stable coronary syndromes. Statin therapy lowers the risk of recurrent events for many years but also reduces the risk of another event within the weeks to months following the initial acute coronary syndrome. The mechanisms that contribute to this benefit are likely related to improved endothelial function, decreased vascular inflammation, and reduced prothrombotic factors. Observation studies show an early reduction in mortality with statin therapy started before discharge from the hospital after an acute coronary syndrome.
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SABCS Interview SeriesThe January issue of OBTN featured highlights from the 32nd Annual San Antonio Breast Cancer Symposium (SABCS). We wrap up our SABCS coverage this month with interviews on denosumab with Alison Stopeck, MD, associate professor of medicine at the University of Arizona and director of the Clinical Breast Cancer Program at the Arizona Cancer Center; oral bisphosphonates with Rowan T.Chlebowski, MD, PhD, professor and chief of the Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles Medical Center; and adjuvant chemotherapy�induced alopecia with Hugues Bourgeois, MD, Centre Jean Bernard in Lemans, France.
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New Guidelines Back Mammograms Starting at Age 40The American College of Radiology and the Society of Breast Imaging have issued new guidelines recommending that mammograms begin at 40 for women with an average risk of breast cancer and by 30 for high-risk women.
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Can You Hear Me Now?Despite major advances in communication technologies, numerous hospitals and clinics still use overhead paging, intercoms, Walkie Talkies, and other antiquated methods to reach staff members.
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Noninvasive assessment of coronary artery bypass grafts with 64-slice computed tomographic angiographyWe evaluated the accuracy of the 64-slice computed tomography (CT) angiography scanner in subjects who were scheduled to undergo invasive angiography for possible stenosis in coronary artery bypass grafts. Results showed that the improved resolution of CT scanners with 64-slice technology allowed for a precise delineation of bypass graft occlusion or stenosis. It permitted an accurate noninvasive assessment of bypass grafts, even in subgroups of subjects with suboptimal scan conditions, such as those with arrhythmias or higher heart rates.
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Medication May Worsen Sleep Instability in Patients with Parkinson DiseasePatients with Parkinson disease had more pronounced sleep instability than those with other disorders marked by alpha-synuclein buildup, but those differences diminished after adjusting for medication differences, a new study found.
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Effect of Inadequate Response to Treatment in Patients With DepressionThis study sought to assess the effects of inadequate response to antidepressant treatment on healthcare resource utilization and on work productivity in patients diagnosed as having major depressive disorder.
