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MI and Ischemic Heart Disease in Overweight and ObesityA review of the relationship between body mass index, metabolic syndrome, and cardiovascular disease and all-cause mortality.
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Long-term Effects of Post-transplant Respiratory Viral InfectionsData suggest respiratory infections in transplant patients are associated with increased long-term mortality and morbidity.
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Improved retinopathy in a patient with type 1 diabetes: A review of the role for HMG-CoA reductase inhibitors in the treatment of diabetic retinopathyA 36-year-old Hispanic man was diagnosed with type 1 diabetes in 1987 and dyslipidemia in 2001.
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More Intensive Blood Pressure Goals Reserved for Most Severe Kidney Disease: KDIGORecent updates by the 8th Joint National Committee (JNC 8), the American and International Societies of Hypertension (ASH-ISH), and KDIGO recommend target blood pressure of less than 140/90 mm Hg for most individuals, including those with CKD.
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5-FU Dose Optimization: Another Step Towards Personalizing Cancer CareAccording to the Centers for Disease Control and Prevention, colorectal cancer is the second leading cancer killer in the United States, affecting both men and women.
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Another Study Shows No Malignancy after BiologicsRheumatoid arthritis patients who have had a malignancy and are receiving a TNFi or rituximab (RTX), do not appear to have an increased risk of cancer recurrence.
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Association between stroke risk and body mass index in womenThe study by Kurth and Buring consisted of a prospective analysis among nearly 40 000 women participating in the Women's Health Study.
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Anomalous origin of the right coronary artery in an asymptomatic athlete: What if he did not have a murmur?Sudden death in young athletes is shocking because it is unexpected in these seemingly healthy individuals. We present the case of an athlete who was found to have an incidental murmur during a screening physical, which led to a diagnosis of an anomalous origin of the right coronary artery with an intramural course. This congenital anomaly has been well recognized to result in sudden death; thus, it was fortunate that the condition was identified in our patient. We provide a brief overview of the literature, discuss the challenges faced in diagnosing such coronary abnormalities, and review the various management options that are available.
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Higher All-Cause Mortality Associated with Hyponatremia in Chronic Kidney DiseaseStudy results show hyponatremia is closely associated with all-cause mortality in patients with chronic kidney disease (CKD), but few previous studies have examined this relationship.
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Tales of the Anion Gap, Part II: Metabolic AcidosisIn this installment, we look at underlying causes of metabolic acidosis, approaches for evaluating patients with suspected metabolic acidosis, and why measurement of the anion gap is of great usefulness in these cases.
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Increased risk of cardiovascular disease among middle-aged women due to glycemic loadWe conducted a study among 15 714 Dutch middle-aged women consuming modest-glycemic-load diets. Results showed that high dietary glycemic load and glycemic index increased the risk of cardiovascular disease. This association was particularly evident among overweight women. Recommendations to follow a high-carbohydrate diet may therefore not be optimal in the prevention of cardiovascular diseases.
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Transcatheter Aortic Valve Replacement Is an Effective Alternative to Surgical ReplacementData from the PARTNER cohort A trial show transcatheter aortic valve replacement produces similar mortality rates at one year compared with the standard procedure.
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Regular Visits with Provider Key to Patients Maintaining Weight Loss from Lifestyle ModificationsThe 2013 revision of guidelines on managing overweight and obesity in adults suggests that providers and patients set a goal of a sustained weight loss of 3-5% of baseline body weight to obtain improvements in triglycerides, blood glucose, HbA1c, and the risk of developing type 2 diabetes mellitus.
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Chest pain syndrome in women: A diagnostic dilemmaThe ability to diagnose coronary artery disease (CAD) in women may be limited by the sensitivity and specificity of symptoms as well as of noninvasive testing. The choice of which test should be performed to evaluate the presence of CAD in women remains controversial. Currently American Heart Association/American College of Cardiology guidelines recommend initial evaluation with exercise electrocardiogram (ECG) testing. In a meta-analysis of 3721 women, however, exercise ECG had a sensitivity of 61% and a specificity of 70%1 as compared to 68% sensitivity and 77% specificity in men.
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Cholesterol-lowering therapies and C-reactive proteinLow-density lipoprotein (LDL) cholesterol-lowering therapy decreases C-reactive protein (CRP) levels, but the importance of LDL cholesterol-independent effects is uncertain because of the variability in measuring LDL cholesterol and CRP levels in any individual patient. In this study, this variability was reduced by comparing average changes in LDL cholesterol and CRP levels after treatment with lipid-lowering therapy across different studies.
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Novel Oral Testosterone Replacement Therapy Is Safe and Effective in Clinical TrialsTreatment with LPCN 1021 restored and maintained testosterone levels at rates comparable to approved non-oral products.
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Is circulating heat shock protein 60 a marker for susceptibility to cardiovascular disease in patients with diabetes?The vital cell stress protein, heat shock protein (Hsp)60, has recently been found in the circulation of healthy subjects over an extremely large concentration range. We performed an analysis of subjects with diabetes to determine whether Hsp60 is associated with biochemical markers of cardiovascular disease. Results showed that high circulating levels of Hsp60 are associated with clinically manifest cardiovascular disease. Hsp60 has cytokine-like actions, which may be responsible for this association.
