John McMurray, MD: DAPA-CKD and Cardiorenal Protection

An analysis comparing the results of patients with and without cardiovascular disease at baseline from within the landmark DAPA-CKD trial is providing clinicians with further evidence of the cardioprotection seen with dapagliflozin (Farxiga).

Just a few months after initial results were presented at ESC 2020, the latest analysis concluded the effects of dapagliflozin seen in DAPA-CKD, which includes reductions in risk of kidney failure and risk of worsening heart failure, were consistent regardless of a patient’s history cardiovascular disease.

Presented by John McMurray, MD, professor at the University of Glasgow, at the American Heart Association (AHA) Scientific Sessions 2020, results of the DAPA-CKD analysis build on the previously established safety and efficacy profile of the SGLT2 inhibitor. In the original trial, dapagliflozin was associated with a reduction in risk of the primary end point of preventing worsening kidney function or death from kidney disease or cardiovascular disease by 39%—with reductions of 36% and 50% in patients with and without diabetes, respectively.

In the present analysis, stratification by cardiovascular history at baseline indicated the effect of dapagliflozin on the primary endpoint, cardiovascular disease/heart failure, all-cause mortality were maintained (P for interaction >.05 for all).

For more on the results of this analysis and what it tells clinicians about dapagliflozin in patients with chronic kidney disease and a history of cardiovascular disease, Practical Cardiology invited McMurray to take part in a special edition AHA 2020 House Call.

This study, “Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD),” was presented at AHA 2020.