Matt Hoffman

Patients with hospital-acquired sepsis had higher rates of congestive HF, cerebrovascular disease, need for mechanical ventilation and vasopressors, increased LOS, more ICU days, and higher mortality than those with community-acquired sepsis.

The approval was granted based on efficacy and safety data from the Escort-HU study, which included 495 pediatric patients with sickle cell anemia.

The risk of myocardial infarction was 2.4-fold higher in patients on short-term P2Y12 inhibitors after 18 months and 5.1-fold higher from month 6 to month 18.

Andexanet was shown to reduce FXa inhibition activity by 91% for patients on apixaban, 88% for patients on rivaroxaban, and 75% for patients on enoxaparin.

As canakinumab lowers hsCRP, as well as interleukin-6, without a negative effect on lipid levels, it characterizes a new class of atherosclerosis medications.

The combined efforts of coaxing from barbers and monthly in-shop care from pharmacists resulted in 63.6% of the cohort achieving target BP levels.

The CVD-REAL 2 study found that compared with other glucose-lowering drugs, SGLT-2 inhibitors reduce all-cause death, hospitalization for heart failure, myocardial infarction, and stroke.

While receiving a large dose of statin therapy did not have an impact on major adverse cardiac events among a broad population of patients, those that underwent percutaneous coronary intervention saw reductions.

The mSToPS trial revealed a wearable ECG patch can markedly increase the AFib diagnosis rate relative to routine care—as much as 9-fold in the short-term and 3-fold in the long-term.

The use of instantaneous wave-free ratio can reportedly save each patient at least $800 in comparison with fractional flow reserve.

While full parity may be impossible, a 4-step protocol did decrease discrepancies in clinical outcomes and mortality between men and women.

Clinicians have been shown to be influenced by their patients’ genetic makeup when prescribing antiplatelet therapies.

All-cause mortality and death due to stroke, however, were 1.8% and 0.5% lower, respectively, in the group utilizing WCD.

The trial showed alirocumab reduced MACE by 24% with an ARR of 3.4% and all-cause death by 29% with an ARR of 1.7% in patients with ACS and baseline LDL-C ≥100 mg/dL.

For patients with perinatal HIV, ART has essentially made the infection a chronic, but manageable, health condition.

As the use of e-cigarettes increases in the US, allergists and pulmonologists should ensure they educate their patients about the risks.

Raltegravir exposure was roughly doubled by sodium bicarbonate, whereas aluminum/magnesium hydroxide did not exhibit the same effect.

The tests can distinguish Babesia microti antibodies in plasma samples, and the in whole blood samples.

The therapy is currently approved for use by adults with bipolar depression and for the treatment of schizophrenia in patients aged 13 and older.

By looking back on the early days of the HIV/AIDS epidemic, the medical community can learn many lessons.

Mepolizumab reduced Asthma Control Questionnaire scores from baseline by –1.45 in patients that had uncontrolled asthma with omalizumab.

KIT inhibition with imatinib reduced mast cells in patients with severe asthma in a proof-of-concept trial, but is the treatment feasible for the future?

While multi-faceted approaches have been shown to be cost-effective, realistically they can be costly and impractical to implement. But environmental and educational interventions hold some promise.

Despite being the traditional practice, increasing inhaled controller therapy doses during yellow-zone episodes does not stop asthma exacerbations.

Re-examination revealed that alpha-gal allergy resulted in a change in the identification of definitive anaphylaxis triggers in 25% of cases.

Patients with a peanut allergy that can only tolerate low doses of oral immunotherapy can still achieve desensitization.

While the data have been met with conflicting opinions, environmental interventions for allergens in the home hold potential for asthma.

Persistent cow's milk allergy may negatively impact height, weight, and BMI through adolescence.

Policy interventions and medication are the best available methods for improving the negative impact pollutants have on patients.

Improving asthma management in schools not only benefits pediatric patients' health, but improves attendance rates.