February 2010

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins is one of only 40 cancer centers in the country designated by the National Cancer Institute as a Comprehensive Center. The physician researchers at the institution have been characterizing the acquired genome defects in cancers for the better part of the past few decades.

Executives at Radient Pharmaceuticals Corporation may one day look back on 2009 as the year when the coming-out party for the two-decades-old firm located in Tustin, California, began.

If there is such a thing as a business trifecta, Seattle Genetics is nearly there. The Washington state biotechnology company is focused on the development and commercialization of monoclonal antibody–based therapies for the treatment of cancer and autoimmune disease. And with a potent pipeline of potential products and numerous technology and marketing collaborations in place, the opportunities for growth are in the air.

A study presented at the 51st American Society of Hematology Meeting and Expedition reported that 5 days of palonosetron (Aloxi) was significantly more effective than ondansetron at preventing delayed chemotherapy-induced nausea and vomiting (CINV) in patients with acute myelogenous leukemia (AML).

Scientists at Fred Hutchinson Cancer Research Center in Seattle, Washington, successfully tested a mechanism that increases the number of progenitor cells extracted from a unit of human umbilical cord blood. The laboratory method potentially solves the 1- to 2-month delay in myeloid engraftment after cord blood transplantation (CBT).

At the 2010 Gastrointestinal Cancers Symposium, new data from the CRYSTAL trial identified BRAF gene mutations as a poor prognostic indicator in metastatic colorectal cancer (mCRC) but not predictive of response to therapy.

The American Recovery and Reinvestment Act (ARRA) of 2009 designated $87 billion for state Medicaid programs, enacting major increases in federal matching rates. Despite the boost from ARRA, state budgets have been groaning under the weight of the economic downturn, with 29 of them planning to make Medicaid cuts in 2010.

The use of oral oncolytics is increasing, with 14 approved already and nearly one-quarter of the oncology pipeline consisting of oral therapies. Despite this, the Community Oncology Alliance (COA), a nonprofit organization that advocates for patients and providers in the community oncology setting, said many patients still have difficulty getting access`to targeted oral oncolytics.

The potential federal healthcare overhaul engendered a bitter debate over rumored "death panels" making end-of-life decisions for patients. Although the claims were never substantiated, the furor directed the nation's attention to the important issue of end-of-life care.

The December issue of Oncology & Biotech News featured highlights from the 51st American Society of Hematology (ASH) Annual Meeting and Exposition. We wrap up our ASH coverage this month with interviews on multiple myeloma with Brian G.M. Durie, MD, medical director and co-founder of the International Myeloma Foundation; chronic lymphocytic leukemia (CLL) with Robert J. Kreitman, MD, from the National Cancer Institute; and chronic myeloid leukemia (CML) with Francis J. Giles, MD, Cancer Therapy and Research Center at The University of Texas Health Science Center in San Antonio.

Participation in clinical trial research is essential to continued improvement in cancer care. Yet, fewer than 10% of U.S. adults enroll in trials. A recent US Oncology�sponsored survey found that most oncologists remain optimistic about the future of clinical trial research. We discuss obstacles to clinical trial enrollment with Nicholas Vogelzang, MD, and Matthew Galsky, MD, of the Comprehensive CancerCenters of Nevada.

The Third Annual Interdisciplinary Prostate Cancer Congress (IPCC) will take place on Saturday March 27, 2010, in New York City.

A persistent concern about using marijuana for medical purposes has been the lack of clinical trials demonstrating marijuana's effectiveness in any of the conditions for which it is legally prescribed in many states. Now, a team of researchers from the University of California San Diego School of Medicine's Center for Medicinal Cannabis Research (CMCR) has presented a summary of studies to the California legislature that claims smoking marijuana relieves pain in several chronic illnesses.

On January 29, the FDA expanded indications for lapatinib (Tykerb) to include its use in combination with the aromatase inhibitor letrozole (Femara) to treat hormone-positive and HER2-positive advanced breast cancer in postmenopausal women.

Healthcare reform (HCR) is complicated, not only because of the diversity of options but also the range and passion of opinions on the subject. Physicians are in the unique position of being able to see the debate from multiple angles. Yet, it does not take a physician to recognize that the current healthcare system is unsustainable.