Endo 2010 Abstract Roundup (Part 2)

Abstract #P2-557HbA1c May not Be a Specific Determinant of Diabetic Status in the ElderlyAuthors: Tay T, Chen R, Cho L, et al.

Purpose: The authors aimed “to determine the impact of age on the appropriate cut off value of HbA1c in relation to the diagnosis of type 2 diabetes mellitus in our local population.”

Results: This cross-sectional study of 90 predominantly Chinese patients “(mean age 60.9 years, range 20 to 93) without prior history of T2DM” found that “Hb1Ac had a low specificity for diagnosing T2DM in older Asian subjects, suggesting that caution needs to be exercised in using HbA1c in isolation. Other metabolic parameters such as BMI are predictive of T2DM, and should be taken into consideration, especially in older adults.”

Abstract #OR24-2Roux-en-Y Gastric Bypass Surgery in T2DM Patients is Superior to Low Calorie Diet in Improving Insulin Sensitivity and Beta-cell Function Despite Equivalent Weight LossAuthors: Plum L, Febres G, Ahmed L, et al.

Purpose: “This study investigates whether effects unique to RYGB improve insulin sensitivity and beta cell function independent of simultaneous enteral nutrient passage.”

Results: “Insulin sensitivity and adiponectin levels, as well as beta cell function in diabetic RYGB patients showed better improvement compared with LCD patients, despite equivalent weight loss and cessation of anti-diabetic medications. These data reaffirm a beneficial glucotastic effect of RYGB in T2DM patients that occurs independent of acute enteral nutrient passage and fasting gut hormone levels.

Abstract #P3-432Laparoscopic Gastric Banding Surgery for Patients with Type 2 Diabetes and Morbid Obesity: Improving BMI and Psychological Status at 1 Year Post-srugeryAuthors: Jackson S, Morris M, Lilley K, et al.

Purpose: Despite the fact that “surgical treatment is increasingly recognized as the most effective means of achieving weight loss and improving glucose tolerance in morbidly obese patients with T2DM…the long-term psychological status of morbidly obese individuals (both with and without T2DM) undergoing LAGB remains unclear despite its increasing use.”

Results: “Repeated measures ANOVA resulted in significant improvements across the three time points being recorded for BMI & HbA1c (both p<.001), the psychological and physical subscales of the quality of life measure (both p<.001). While both BMI and HbA1c significantly improved at all time points, a different pattern was observed for the psychological variables. Significant improvements were observed between pre- and six months post-LAGB, and between pre- and 12 months post-LAGB on the WHOQoL subscales, the HADS subscales and the DAS-24. However, no significant gains were specifically recorded for these measures between T2 and T3, although an improving trend was noted.”

Abstract #P3-428Oxidative Stress and Metabolic Syndrome: Effects of Natural Dietary Antioxidants in Obese Patients with Insulin ResistanceAuthors: Mancini A, Martorana G, Donna D, et al.

Purpose: “Oxidative stress could play an important role in metabolic syndrome-related manifestations contribution to insulin reistance. The reciprocal influences between OS and IR are not clear. We investigated the effects of dietary antioxidants on IR, studying 29 obese (16 males and 13 females, 18-66 years, BMI 36.0±1.0 Kg/m2), with IR evaluated by HOMA index, comparing 4 treatments: hypocaloric diet alone (group A) or plus metformin 1000 mg/daily (group B), diet enriched with natural antioxidants alone (group c) or plus metformin (group d).”

Results: “Despite a similar BMI decrease, we found a significant decrease in group D (25.60±8.96%). No differences were observed in glucose AUC and lipid metabolism and LAG values. These data suggest that dietary antioxidants amerliorate insulin-sensitivity in obese subjects with IR enhancing the effect with insulin-sensitizing drugs, although the molecular mechanisms still remain to be elucidated.”

Abstract# P3-721A Multifactorial Approach to Prevent Adiposity and Improve Fitness in Predominantly Migrant Preschool Children: Cluster-randomized Controlled Trial (the Ballabeina Study)Authors: Puder J, Marques-Vidal P, Zahner L, et al.

Purpose: “To assess the effectiveness of a multifactorial lifestyle intervention program on adiposity and fitness in preschool children.”

Results: “Forty preschool classes from areas with a high migrant population were randomly selected and randomized into and intervention (n=20) and a control (n=20) arm by the use of opaque envelopes after stratification for language region (French vs. German part of Switzerland).” The researchers instituted a program that “increased physical activity, promotion of health nutritional behavior and sleep and [reduced] media use…through lessons, infrastructural changes and involvement of parents and teachers.” Though there was no difference in BMI between groups, the intervention group experienced “a more favorable improved performance in aerobic and overall fitness…and significant relative decreases in body fat, % body fat, and waist circumference…There were significant differences in reported, but not in measured physical activity, in media use, and some aspects of nutritional behavior, but not in sleep duration.”