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Endocrine Case Report: Weak and Thirsty

This endocrine case report from Brady Pregerson, KMD, features a woman in her mid-30s with a history of cerebral astrocytoma status post radiation therapy presenting with generalized weakness, a gradual onset generalized headache, and excessive thirst. Can you determine the correct diagnosis?

History of Present Illness:

A patient in their mid-30s with history of cerebral astrocytoma status post radiation therapy presents to the hospital with generalized weakness, a gradual onset generalized headache and excessive thirst. She denies any recent fevers or any nausea/vomiting/diarrhea, black or bloody stool or other complaints. There have been not seizures, falls or injuries.

Vital Signs & Physical Exam:

Vital signs are normal except for mild blood pressure elevation. The physical exam is essentially normal and the oropharynx does not look dry.

Initial Diagnostic Testing:

CBC: Normal

Chem-7: The sodium is very high at 163 with elevated chlorine as well. Other values are essentially normal.

Imaging: Brain CT showed no significant change from baseline.

What is the most likely diagnosis?


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