Ginger Constantine from EndoRheum Consultants: Developing New Treatments to Help Postmenopausal Women with Sex

As women age and enter menopause, there are a number of new health issues they face. One of those possible delicate issues is pain during sex; but a new medication looks to ease this problem.

Ginger Constantine, MD, EndoRheum Consultants, spoke about a novel, estrogen-based soft gel capsule, TX004HR, is in clinical development, to help postmenopausal women. The aim is to help women who experience pain during sex due to dyspareunia and vulva/vaginal atrophy.

Constantine said that although treatments such as lotions, creams, and other estrogen treatments exist, a significant number of women are not treated at all for this condition. The recent phase 3 clinical trial examined three dose application of TX004HR versus a placebo.

“The study showed very significant statistical improvements in the objective measures,” Constantine said, referring to the cell stimulation and the pH improvements. She added that dyspareunia declined, and the dosage also helped with the issue of vaginal dryness.

“The dosing is quite low, and there is a great efficacy with very low systemic absorption,” she said, adding this could give postmenopausal women another option in addressing pain during intercourse.

“It gives women another option. Only two million out of 30 million women are treated.”

The side effects of TX004HR were negligible headache in some patients.