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Flares of rheumatoid arthritis have been linked to higher disease activity, lower quality of life, and increased radiographic progression.
1. Bechman K, Tweehuysen L, Garrood T, et al. Flares in rheumatoid arthritis patients with low disease activity: predictability and association with worse clinical outcomes. J Rheumatol. 2018;45:1515-1521. doi: 10.3899/jrheum.171375.