Article

Multicenter Trial to Investigate Sodium Management in Patients with Acute Neurological Injury

Investigators at more than one dozen sites will enroll hundreds of neurologically injured patients to study the effects of low serum sodium concentrations prior to therapy.

Investigators at more than one dozen sites will enroll hundreds of neurologically injured patients to study the effects of low serum sodium concentrations prior to therapy.

Investigators are looking to enroll 400 adult (age ≥ 18 years of age) men and women who have been admitted to an intensive care unit for more than 48 hours with ICD-9 codes for aneurysmal subarachnoid hemorrhage (SAH), traumatic brain injury (TBI), intraparenchymal hemorrhage (IPH), or intracranial tumor.

The Sodium Management in Patients with Acute Neurological Injury observational study will “enroll severe neurologically injured patients both prospectively and retrospectively. The aims are to identify the percent of neurocritical care patients with sodium levels ≤ 135 mEq/L, describe treatment strategies employed, determine the correlation of clinical factors (ie, GCS, ICP) with serum sodium concentrations in patients prior to sodium altering therapy, and evaluate outcomes through evaluation of length of stay, discharge disposition, and modified Rankin score (mRS).”

Participating centers are located in Connecticut, Florida, Georgia, Illinois, Kansas, Kentucky, Maryland, Michigan, Missouri, New York, Ohio, Tennessee, and Virginia.

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