Article

RA Quiz: What if methotrexate fails?

Author(s):

Ingrid Torjesen

Methotrexate is considered first-line therapy for rheumatoid arthritis, but if this fails to control symptoms, it is time to consider a second-line therapy. TNF inhibitors and IL inhibitors are options, but which to choose? Learn more in this quiz.

In general, what drug does the American College of Rheumatology recommend be considered first for patients with moderate or high disease activity despite DMARD therapy: a TNF inhibitor or a non-TNF biologic such as an IL inhibitor?


Related Videos
Kimberly A. Davidow, MD: Elucidating Risk of Autoimmune Disease in Childhood Cancer Survivors
Matthew J. Budoff, MD: Examining the Interplay of Coronary Calcium and Osteoporosis | Image Credit: Lundquist Institute
Orrin Troum, MD: Accurately Imaging Gout With DECT Scanning
John Stone, MD, MPH: Continuing Progress With IgG4-Related Disease Research
Philip Conaghan, MBBS, PhD: Investigating NT3 Inhibition for Improving Osteoarthritis
Rheumatologists Recognize the Need to Create Pediatric Enthesitis Scoring Tool
Presence of Diffuse Cutaneous Disease Linked to Worse HRQOL in Systematic Sclerosis
Alexei Grom, MD: Exploring Safer Treatment Options for Refractory Macrophage Activation Syndrome
Jack Arnold, MBBS, clinical research fellow, University of Leeds, Leeds Institute of Rheumatic and Musculoskeletal Medicine
John Tesser, MD, Adjunct Assistant Professor of Medicine, Midwestern University, and Arizona College of Osteopathic Medicine, and Lecturer, University of Arizona Health Sciences Center, and Arizona Arthritis & Rheumatology Associates
Related Content
Perceived Stressed Associated With Symptom Burden in People With Fibromyalgia
February 5th 2025

Perceived Stressed Associated With Symptom Burden in People With Fibromyalgia

Victoria Johnson
Emerging Agents in the Treatment of Rheumatic Diseases
October 2nd 2023

Emerging Agents in the Treatment of Rheumatic Diseases

Nehad Soloman, MD, FACR Andrew Sharobeem, DO, FACR Philip J. Mease, MD
HCPLive Rheumatology Month in Review
February 3rd 2025

Rheumatology Month in Review: January 2025

Victoria Johnson
Challenges with Step Therapy Protocols in Treating Rheumatoid Arthritis
August 31st 2023

Challenges with Step Therapy Protocols in Treating Rheumatoid Arthritis

Nehad Soloman, MD, FACR Andrew Sharobeem, DO, FACR John B. Boone, MD, FACR Madelaine Feldman MD, FACR
Fibromyalgia Common in People With IBD
January 28th 2025

Fibromyalgia Common in People With IBD

Victoria Johnson
Orrin M. Troum, MD, Division of Rheumatology, University of Southern California Keck School of Medicine and Providence Saint John’s Health Center
January 26th 2025

Pegloticase + MTX for Gout Not Effective After Pegloticase Monotherapy

Victoria Johnson
© 2025 MJH Life Sciences

All rights reserved.