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Smoking, obesity, RF and anti-CCP positivity, high disease activity, early erosions-one of these was found to protect against severe joint damage.
Reference1. Rydell E, Forslind K, Nilsson JÃ , Jacobsson LTH, Turesson C. Smoking, body mass index, disease activity, and the risk of rapid radiographic progression in patients with early rheumatoid arthritis. Arthritis Res Ther. 2018;20:82. doi: 10.1186/s13075-018-1575-2.