Article

Women, Minorities and Older Adults Still Underrepresented in Clinical Trials: Conversation with Erin Michos MD

The outcomes of clinical trials are often affected by the diversity of the patient population studied.  Things like race and gender can make a real difference in the way drugs work– and yet women, minorities and older adults continue to be underrepresented in pivotal trials for new medications .  Two recent studies demonstrate that fact over the last several decades.  And although the proportion of these populations enrolled in clinical trials has increased, it is still well out of step with the number of patients affected by the diseases in question. Sr. Editor Gretchen Cuda Kroen spoke with Dr. Erin Michos,  co-author on those studies about the origins of the disparity, and what what we can do about it.

The outcomes of clinical trials are often affected by the diversity of the patient population studied.  Things like race and gender can make a real difference in the way drugs work– and yet women, minorities and older adults continue to be underrepresented in pivotal trials for new medications .  Two recent studies demonstrate that fact over the last several decades.  And although the proportion of these populations enrolled in clinical trials has increased, it is still well out of step with the number of patients affected by the diseases in question. Sr. Editor Gretchen Cuda Kroen spoke with Dr. Erin Michos,  co-author  on those studies about the origins of the disparity, and what what we can do about it.

Khan MS, Shahid I, Siddiqi TJ, et al. Ten-Year Trends in Enrollment of Women and Minorities in Pivotal Trials Supporting Recent US Food and Drug Administration Approval of Novel Cardiometabolic Drugs. J Am Heart Assoc. 2020;9(11):e015594. doi:10.1161/JAHA.119.015594

Khan SU, Khan MZ, Raghu Subramanian C, et al. Participation of Women and Older Participants in Randomized Clinical Trials of Lipid-Lowering Therapies: A Systematic Review. JAMA Netw Open. 2020;3(5):e205202. Published 2020 May 1. doi:10.1001/jamanetworkopen.2020.5202

 

Related Videos
Brigit Vogel, MD: Exploring Geographical Disparities in PAD Care Across US| Image Credit: LinkedIn
| Image Credit: X
Ahmad Masri, MD, MS | Credit: Oregon Health and Science University
Ahmad Masri, MD, MS | Credit: Oregon Health and Science University
Stephen Nicholls, MBBS, PhD | Credit: Monash University
Marianna Fontana, MD, PhD: Nex-Z Shows Promise in ATTR-CM Phase 1 Trial | Image Credit: Radcliffe Cardiology
Zerlasiran Achieves Durable Lp(a) Reductions at 60 Weeks, with Stephen J. Nicholls, MD, PhD | Image Credit: Monash University
Muthiah Vaduganathan, MD, MPH | Credit: Brigham and Women's Hospital
Viet Le, DMSc, PA-C | Credit: APAC
Marianna Fontana, MD, PhD: Declines in Kidney Function Frequent in ATTR-CM  | Image Credit: Radcliffe Cardiology
© 2024 MJH Life Sciences

All rights reserved.