Robert S. Gillespie, MD, MPH

Nephrotic syndrome is a common disease in children. Minimalchange disease remains the most frequent cause, but a careful evaluation to exclude other renal conditions is important, particularly to distinguish between isolated nephrotic syndrome and nephrotic syndrome with nephritis. Corticosteroids and sodium restriction form the mainstay of therapy. Although most patients with isolated nephrotic syndrome recover quickly without major sequelae, the physician must remain alert for signs and symptoms of serious complications. Detailed patient and family education, along with close follow-up and support, will help ensure the best outcomes.