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Trial for Anti-Lung Cancer Compound ASA404 Progresses to Phase IIIA pivotal phase III study is currently underway to evaluate the efficacy and safety of Novartis' novel anti-cancer compound ASA404 in patients with non–small cell lung cancer (NSCLC). NSCLC is the most prevalent cause of cancer death among men and women in the United States and globally.
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The Ratings GameThe rise of social networking websites that encourage patients to rate their physicians and discuss their experiences has some practitioners worried about the damage a malicious review could do to their practice.
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One Health: New term, Ancient ConceptHow the 9/11 terrorist attacks encouraged the evolution of The One Health Initiative and what that means for the future of medicine.
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What Should I Do With This Abnormal ALT?You see a 48-year-old white man for his annual examination. . The patient is overweight with a body mass index (BMI) of 32. A screening chemistry panel is normal except for an aspartate aminotransferase (AST, formerly SGOT) level of 85 U/L (normal 15-50 U/L) and an alanine aminotransferase (ALT, formerly SGPT) level of 98 U/L (normal 5-50 U/L). He says you are the first doctor he has seen in more than 10 years and does not recall the last time he had a blood test.
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Clinical Trial Disparities: A Case for DiversityThe challenge of eliminating disparities in clinical trials is being addressed by the Eliminating Disparities in Clinical Trials (EDICT) project, which recognizes that broadening diversity in clinical trials will result in improved effectiveness and safety of future medicines, improved trial quality, and reduced discrepancies in health equity.
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How do cardiac and noncardiac conditions affect survival after ICD implantation?The benefits of implantable cardioverter-defibrillators (ICDs) have been shown in randomized clinical trials. The factors that affect the risk–benefit ratio in a community setting, however, have not been evaluated.
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Does revascularization improve quality of life in elderly diabetic patients with angina pectoris?It is difficult to make generalizations about treatment of elderly diabetic patients with coronary artery disease (CAD).
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Stress echocardiography in diabetes mellitusWe assessed how well dobutamine stress echocardiography predicted morbidity and mortality in 2349 patients with diabetes mellitus over a follow-up period of 13.2 years. Results showed that age, failure to achieve the target heart rate, and the percentage of ischemic segments were independent predictors of both mortality and cardiovascular morbidity. Using clinical and stress echocardiographic parameters, a simple model for risk stratification was developed.
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Continuous Glucose Monitoring Helps Even Well Controlled Type 1 DiabeticsAccording to a report in the August 2009 issue of Diabetes Care, even when patients with type 1 diabetes have excellent hemoglobin A1C levels, continuous glucose monitoring will be beneficial.
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VoceraLarge organizations with mobile workers, such as hospitals, face diminished productivity when communication is inefficient and its employees are unable to locate their coworkers in a timely manner.
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Historic Phase 3 Microbiota Trial for C Diff Treatment Completes EnrollmentRBX2660 from Rebiotix will be assessed in a randomized study involving 300 patients.
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Iatrogenic dilated cardiomyopathy and spectrum of current treatment modalitiesOur increasing ability to intervene in high-risk patients—with lower risks and greater chances for successful outcomes—is felt across the broad spectrum of cardiovascular disease. This is particularly evident in patients with dilated cardiomyopathy (DCM).
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Updated Recommendations for Gestational Diabetes Streamline Screening MethodsIn response to the growing prevalence of gestational diabetes mellitus and its associated morbidities, much attention has been paid to the use of appropriate screening methodologies for the metabolic disorder.
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The role of angiotensin-converting enzyme inhibitors in patients with stable coronary artery disease and preserved left ventricular systolic functionAngiotensin-converting enzyme (ACE) inhibitors have been shown to be beneficial in the management of multiple cardiovascular disease states.
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Nonischemic cardiomyopathy and implantable cardioverter-defibrillatorsWe assessed whether duration of nonischemic cardiomyopathy was related to the degree of benefit from implantable cardioverter-defibrillator (ICD) insertion. Subjects who had a recent diagnosis of nonischemic cardiomyopathy had at least a similar benefit from ICD insertion as did those with a remote diagnosis. These results indicate that ICD therapy should be considered in such patients as soon as they are diagnosed and once reversible causes of left ventricular dysfunction have been excluded.
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Is warfarin a safe alternative to aspirin in elderly patients with atrial fibrillation?We recruited 973 patients (mean age, 81 years) with atrial fibrillation from the primary care setting and randomly assigned them to receive anticoagulation with warfarin or aspirin.
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Psychological Factors May Explain Treatment Gaps for Patients with DepressionConflicts between identity and depressive symptoms may account for the significant delays in help-seeking by patients with depression, according to research published October 2, 2012 in BMC Psychiatry.
