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Intensive statin therapy in acute coronary syndromeWe conducted a meta-analysis of 13 randomized controlled trials involving 17 963 subjects to determine the effect of intensive statin therapy instituted within 14 days of hospitalization for acute coronary syndrome. Results showed that early, intensive statin therapy is safe and significantly decreases cardiovascular death and recurrent ischemia following acute coronary syndrome after 6 months of treatment.
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Are Flawed Dose Conversion Calculators to Blame for the Dramatic Increase in the Number of Methadone Overdoses?Although methadone accounts for only 2% of opioid prescriptions, it caused nearly one in 3 prescription opioid overdose deaths in 2012, a 6-fold increase from 2009, according to the CDC.
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The Benefits of Fish Oil and Peanut Butter in Newborns, ChildrenWhile peanut butter exposure aids children from an early age, fish oil could improve asthma rates.
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Case-Based Peer Perspectives in Fabry DiseaseDawn Laney, MS, CGC, CCRC, Assistant Professor and Director, Emory Genetic Clinical Trials Center, talks misdiagnosis in Fabry disease through a case study.
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Screening routines for coronary anomaliesThe case report by Gandhi and Rosenberg illustrates some of the concerns regarding coronary anomalies.
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Comprehensive lifestyle modification and blood pressure controlLifestyle recommendations for the prevention and treatment of hypertension include weight loss, reduced sodium intake, increased physical activity, limited alcohol intake, and the Dietary Approaches to Stop Hypertension (DASH) diet. The 18-month results of the Prospective Registry Evaluating Myocardial Infarction: Events and Recovery (PREMIER) randomized clinical trial showed that individuals with prehypertension and stage 1 hypertension can make and sustain many of these lifestyle changes over the long term, thereby reducing their risk of cardiovascular disease.
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Ultrafiltration for heart failureWe compared the use of early, minimally invasive ultrafiltration with usual care in patients with acute decompensated heart failure in a randomized controlled trial. Ultrafiltration therapy resulted in greater fluid removal than standard therapy and was shown to be a safe and effective alternative to loop diuretics for sodium and fluid homeostasis in patients with heart failure. More research is needed to identify those patients most likely to benefit from this approach.
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Improving Blood ManagementIn this feature article, Ajay Kumar, MD, discusses how the Cleveland Clinic is leveraging technology to refine the use of blood components.
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Extreme lipoprotein(a) levels and myocardial infarctionWe conducted a study to determine whether high lipoprotein(a) levels predicted the risk of myocardial infarction (MI) and ischemic heart disease. Unlike other studies, we measured lipoprotein(a) levels shortly after sampling and corrected for regression dilution bias.
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Study Finds Wide Variation in the Use of Testosterone Therapy among Veterans Health Administration FacilitiesResearchers identify limited evidence base and uneven clinical application as probable reasons for variation.
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ASTRO Patient Portal Now Includes Bone Metastases InformationThe American Society for Radiation Oncology (ASTRO) has added a Radiation Therapy for Bone Metastases section to its patient Website.
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HITECH Lays the Foundation for More Ambitious Outcomes-Based ReimbursementA sophisticated nationwide health information technology infrastructure is required to support changing health care reimbursement models.
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Technology Is Illuminating the Full Spectrum of Care in Oncology NursingIn order to achieve the goals made possible by recent technology advances in oncology nursing practice, nurses will have to endure the growing pains of in-services and devote the necessary time to build expertise and master the new technologies before they can implement them into daily oncology nursing practice.
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Sudden death in patients with myocardial infarctionWe evaluated the risk and timing of sudden death among high-risk patients after myocardial infarction (MI). Among survivors of acute MI with reduced left ventricular systolic function or heart failure, or both, the risk of sudden death from cardiac causes was highest in the first 30 days after MI. These findings indicate a need for early intervention to prevent sudden death during this vulnerable period.
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Effectiveness and Cost-Effectiveness of Diabetes Prevention among Adherent ParticipantsOver 10 years, lifestyle intervention and metformin were cost-effective or cost saving compared with placebo.
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Women and acute coronary syndromesDrs Pfeifer and Steingart (page 11) provide a timely report on recent findings affecting the assessment and treatment of women with acute coronary syndromes.
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Don't Forget to Assess the Family Caregiver of Your Older Adult PatientUnlike assessments of pediatric patients, healthcare providers do not routinely include the family members or friends in the assessment of older adults—but they should.
