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Chronic Leg Ulcer in a Middle-Aged ManA 60-year-old gentleman presented to a clinic with a large ulceration over his left tibia. The wound was friable, erythematous, and purulent, with necrotic involvement of the tibial tendon sheath. He reports that the lesion started 15 years ago and worsened after surgical debridement 10 years ago. High-dose prednisone helped in the past, but other medications have been of no help. Recently, the patient developed intense pain with occasional fevers, chills, and night sweats. He has type 2 diabetes mellitus, but denies any history of bowel difficulties, hepatitis, or arthralgias. What is your diagnosis?
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White-coat hypertension and the development of sustained hypertensionFor 50 years, hypertension has been recognized as the most significant risk factor for the development of symptomatic cardiovascular disease in Western society.
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The Third Annual Gearhead's Holiday Gadget-Buying GuideA brief guide to the must-have gadgets for you and your loved ones this holiday season.
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If Healthcare Reform FailsWhile the changes President Obama and Democratic leaders in Congress are proposing are considerable (they could reduce the deficit within two decades), they aren't a government takeover.
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How Should I manage This Young Woman's Painful Genital UlcersA 29-year-old female accountant is seen by you for painful lesions in the vulva. Her past medical history is notable only for the use of the hormonal contraceptive patch. She has been married for one year and denies a past history of herpes. Examination reveals two mildly tender grouped ulcerative lesions on the left labia.
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Head and Neck Cancer Vaccines Get Orphan StatusEarlier this year, the FDA granted Orphan status to 2 vaccines designed to fight head and neck cancers. Find out how they work and trials in progress.
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Creatine kinase-MB elevation after coronary artery bypass graft surgery in acute coronary syndromesWe evaluated more than 26 000 subjects from 4 large trials that included subjects with non–ST-segment elevation acute coronary syndromes to determine the prognostic importance of creatine kinase-myocardial band (CK-MB) elevation after coronary artery bypass graft (CABG) surgery during the index hospitalization. Results showed that mortality at 6 months increased with increasing peak CK-MB ratios (CK-MB value post-CABG/CK-MB upper limit of normal), and peak CK-MB ratio was an independent predictor of 6-month outcome.
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How Should I Manage This Man's Left Facial ParalysisA 45-year-old male accountant is seen by you complaining that when he awoke this morning, his wife noted a drooping of the right side of his face. Examination reveals a moderate right facial paralysis.
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Aspirin and statins for prevention of coronary artery diseasePracticing cardiologists often joke about putting "statins" in the drinking water to stem the epidemic of atherosclerotic cardiovascular disease, but curiously, I don't believe that refers, even in jest, to a cocktail combination of drugs.
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Localized Chemotherapy Delivery: A Brief ReviewThe concept of treating malignancies using a regional approach originated in 1950, when Klopp and associates began to infuse nitrogen mustard into the arterial supply of various neoplasms.
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Operating in the Global TheaterTwo American couples share what they have learned in over 20 cumulative years of treating the world's neediest patients and detail what it takes to become a successful volunteer surgeon.
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Making What Tastes Good Better For You"If it tastes good, it must be bad for you" is an adage frequently espoused by mothers everywhere in efforts to influence what their children eat. Chocolate, ice cream, bacon, cheeseburgers, and French fries are just some of the foods I remember, which would evoke such a sentiment expressed by my mother during childhood.
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Flash FindingsFast biotech facts and figures. In this issue: 1) Cancer Risk Factors and Mortality 2) Bladder Cancer 3) Testicular Cancer 4) Breast Cancer
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Meckel's Diverticulum in Adults: More Common Than You ThinkMeckel's diverticulum is among the most common congenital defects of the gastrointestinal tract. Although often considered a disorder of childhood, it can also be diagnosed in adults. Meckel's diverticulum is often asymptomatic. When patients present with symptoms, diagnosis is complicated because the features are similar to those of many other gastrointestinal conditions, and traditional imaging studies often do not demonstrate an obvious abnormality. Management is evolving, and there is no consensus on the appropriate approach to treatment. This article discusses the pathophysiology, associated complications, and management options for this often-overlooked condition.
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Medicine and MiraclesAn Ontario historian and hematologist has become perhaps the world's leading expert on the role medicine has historically played in how miracles are assessed by the Catholic Church as part of its process to grant sainthood.
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IPF KOL Discusses Current and Emerging TherapiesAt the most recent American Lung Association LUNGFORCE expo, RDR sat down with Albert Rizzo, M.D. of the Christiana Care Pulmonary and Critical Care Medicine Section to discuss previous, current and emerging therapies for idiopathic pulmonary fibrosis.
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5 questions with Yue XiongThe beat on the people, devices, trends, and companies shaping healthcare... with Yue Xiong, PhD, Professor of Biochemistry and Biophysics, UNC Lineberger Comprehensive Cancer Center.
