Charles Wykoff, MD, PhD: Context of the PANORAMA Trial
PANORAMA is the first prospective study of high-risk patients with non-proliferative diabetic retinopathy, but not DME, in the anti-VEGF era.
Association Between Chronic Conditions and Visual Impairment
After analyzing information from a cohort of more than 380,000, investigators found an association between chronic illnesses and visual impairment.
Increasing Awareness & Screening Efforts Against Diabetic Keratopathy
Approximately half of all patients with diabetes suffer from keratopathy, yet diagnoses are still underwhelming. Annual screenings need to become more standard.
Jason Hsu, MD: Outcomes of Switching from Aflibercept to Ranibizumab
Jason Hsu, MD, and his colleagues at the Wills Eye Hospital presented a study at ARVO 2019 regarding short-term outcomes of patients, with nAMD, who switched from afliberecept to ranibizumab.
Mia Woodward, MD: The Role of Telehealth in Ophthalmology
Mia Woodward, MD, discusses the future of telehealth in ophthalmology and the biggest issues that need to be corrected going forward.
Vivek Patel, MD: Retinal Pathology and Alterations in the Brain
Researchers are using hi-def retinal and neuroimaging techniques to elucidate the relationship between pathology in layers of the retina and downstream brain alterations.
Hossein Ameri, MD: Will CRISPR Fix Retinitis Pigmentosa?
Following the novel gene-editing tech's approval for the treatment of cancer last year, researchers at Roski Eye Institute are exploring its potential to treat ophthalmic disease.
Lan Yue, PhD: Will Nanophotoswitches One Day Restore Sight to the Blind?
Nanophotoswitches have demonstrated promising results in rats. Will they one day improve transduction in damaged eyes, and restore lost vision in humans?
Jennifer Sun, MD: Why Ophthalmologists Need Machine Learning
The burden of ophthalmic disease is rising. How can ophthalmologists rise to meet it?
Aflibercept Reverses Nonproliferative Diabetic Retinopathy Progression
Intravitreal aflibercept injection showed early signs of activity for patients with moderately severe to severe nonproliferative diabetic retinopathy.
Real-World Study Suggests DME Patients Receive Suboptimal Anti-VEGF Dosing
75% of patients with newly-diagnosed, treatment naïve DME received no treatment within 1 year of diagnosis.
IMCgp100 Highly Effective for Advanced Uveal Melanoma
The novel immune-based treatment IMCgp100 demonstrated a 1-year survival rate of 73% for patients with heavily pretreated, advanced uveal melanoma.
Voretigene Neparvovec Benefit Sustained at 3 Years for Inherited Retinal Disease
Voretigene neparvovec demonstrated sustained improvements in vision for patients with biallelic RPE65-mutation–associated inherited retinal disease.
Real-World Study Highlights Undertreatment of nAMD
Outcomes for patients with nAMD in the real-world were inferior to randomized controlled trials due to significant undertreatment.
Hopkins Researchers Grow Attendance to Free Eye Care Screens 152% Using Vouchers
Researchers hypothesized that making eye care screens free also reduced perceived value of the services.
Artificial Intelligence Can Predict Retreatment Intervals in nAMD
An automated artificial intelligence-based system was approximately 70% accurate at predicting optimal retreatment intervals for nAMD.
DRCR's Anti-VEGF Treatment Algorithm Improves PDR Outcomes at 2 Years
The majority of eyes treated in the DRCR Protocol S study had resolved, stable or improved NV at each follow-up visit.
Less Frequent Brolucizumab Non-inferior to Standard Aflibercept for nAMD
Brolucizumab, which could be given every 12 weeks, showed non-inferior improvements in BCVA when compared with aflibercept every 8 weeks.
Intravitreal FA Insert Effectively Controls Uveitis Recurrences
Use of a 0.18 mg fluocinolone acetonide intravitreal insert effectively lowered the rate of uveitis recurrences and cumulative total recurrent episodes.
Paolo Silva, MD: Deep Learning Algorithm Predicts Future DR Severity
The algorithm identified PPL-HMA in 20% of eyes and was associated with a 2-3 fold increased risk of DR progression, development of PDR and receipt of intravitreal injections over 4 years.
Algorithm Detects Diabetic Retinopathy in Retinal Images with 97% Accuracy
The deep learning algorithm was tested on 71,000 images, and offers the potential to significantly increase the speed at which DR can be identified.
Outcomes Worse with Anti-VEGF than PRP in Patients Lost to Follow-Up
Eyes that received only anti-VEGF experienced significantly worse visual acuity from initial visit to final visit.
Artificial Intelligence Effectively Assesses Cell Therapy Functionality
A fully automated artificial intelligence-based system could effectively classify function and potency of cell therapy.
Jason Hsu, MD: Tackling Treatment Adherence in Patients with Diabetic Retinopathy
Anti-VEGF and pan-retinal photocoagulation can be effective, but neither are "one-and-done" therapies. Physicians must be proactive about how they handle patients with PDR.
Several Gene Therapies on Horizon for Retinitis Pigmentosa
A wave of novel gene therapies is on the horizon as treatments for patients with retinitis pigmentosa.
Paul Kaufman Hopeful, Inspired for Future of Glaucoma Research
The esteemed ophthalmologist spoke of novel therapies, importance of collaboration.
Paul Kaufman on Unmet Needs for Glaucoma, Burgeoning Solutions
In the second leg of a weighty interview, Kaufman ruminates on what more is needed.
Nikolas London Details Cross-Sectional Analysis of anti-VEGF Drugs
Study evaluated trials of aflibercept and ranibizumab in retinal vein occlusion.
At-Risk Drivers Can Be Identified by Visual, Cognitive Acuity
Medical tests more accurate than ticket history to identify crash risk.
New Baseline Models of DR Prediction Emerge at ARVO
Study helps modernize a 20-year-old testing model.