On the HCPLive news page, resources on the topics of disease- and specialty-specific medical news and expert insight can be found. Content includes articles, interviews, videos, podcasts, and breaking news on health care research, treatment, and drug development.
Trial to Explore Use of Tesofensine Combination in Patients with Hypothalamic Obesity
Plans for a clinical phase 2a trial to test a combination of tesofensine and metoprolol (Tesomet) for the treatment of hypothalamic obesity in both the United States and Europe are underway.
Compassionate Use Trials of RT001 in 2 Rare Neurodegenerative Disorders Initiated
Two single-patient, Compassionate Use trials for RT001 have been initiated for late onset Tay Sachs (LOTS) disease and familial encephalopathy with neuroserpin inclusion bodies (FEIN or neuroserpinosis).
FDA Approves Treatment for Chronic Lymphocytic Leukemia & Small Lymphocytic Lymphoma
The FDA has approved venetoclax for treatment of patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), with or without 17p deletion, who have received at least one prior therapy.
Phase 1/2 Study of PH1 Treatment, Lumasiran, Yields Positive Results
Positive data regarding phase 1/2 study for lumasiran, an investigational RNAi therapeutic targeting glycolate oxidase (GO) for the treatment of primary hyperoxaluria type 1 (PH1), yielded positive results.
Gilteritinib Proves Promising for the Treatment of FLT3mut + Acute Myeloid Leukemia
Planned analyses of phase 3 trial of gilteritinib as a maintenance therapy after allogeneic hematopoietic stem cell transplantation in patients with Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutations in acute myeloid leukemia (AML).
Combination Therapy Holds Promise for Newly Diagnosed Systemic AL Amyloidosis Patients
Updated research regarding the ANDROMEDA study indicates the efficacy of subcutaneous daratumumab (DARA SC) and cyclophosphamide, bortezomib, and dexamethasone (CyBorD) as a combination therapy in newly diagnosed light chain (AL) amyloidosis patients.
Phase 2 Trial Initiates Dosing of Selective Translation Regulator in Non-GCB DLBCL Patients
The first patient has been dosed in the phase 2 expansion portion of its monotherapy trial of eFT508 for the treatment of relapsed, refractory non-germinal center B cell (non-GCB) diffuse large B cell lymphoma (DLBCL).