On the HCPLive news page, resources on the topics of disease- and specialty-specific medical news and expert insight can be found. Content includes articles, interviews, videos, podcasts, and breaking news on health care research, treatment, and drug development.
The mTOR Pathway's Influence on Stenting Choices in Diabetics
November 17th 2015In non-diabetic patients, researchers have shown sirolimus-eluting stents to be more effective than paclitaxel-eluting stents, leading to better clinical outcomes. Some researchers believe that T2DM attenuates the mammalian target of rapamycin (mTOR) signaling pathway. This could influence the choice of stents, and has created a controversy.
Nasal Dry Powder Glucagon Device Is One Step Closer to Approval
November 17th 2015Severe hypoglycemia is a complication of insulin use that occurs in 20% of insulin-treated patients on a monthly basis. A small number of these patients become unconscious or seize as a result of severe hypoglycemia. Hospitals are prepared to intervene, but often in the community, a Good Samaritan needs to reconstitute and injection dry powder formulations of subcutaneous and intramuscular glucagon for unconscious or seizing patients.
Getting Closer to a Reliable Artificial Human Pancreas
November 17th 2015Despite the many glucose monitoring and insulin delivery devices that are available, many diabetics who use them remain uncontrolled and experience hypoglycemia. Researchers dream of the day that drug-device combinations will track diabetics' glucose levels and deliver appropriate insulin dose.
Leptin: 20 Years of Research on Metabolic Health
November 17th 2015Leptin (an adipocyte-secreted hormone) has been an object of observation since 1994. Its levels in the body are roughly proportional to an individual's amount of adipose tissue. It seems to regulate energy homeostasis, decrease energy intake, and increase energy expenditure. From its discovery, researchers hoped that its manipulation could be useful clinically.
Charlie Sheen Reveals He's HIV-Positive, But His Doctor Says It Won't Kill Him
November 17th 2015Former Two and a Half Men star Charlie Sheen divulged on the TODAY show Tuesday morning that he is infected with HIV (human immunodeficiency virus). And while it can impact everyday life, it is not the be-all and end-all disease that it once was in the 80's.
Corticosteroids Superior to Pentoxifylline for Alcoholic Hepatitis
Management of alcoholic hepatitis consists of a multidisciplinary approach including alcohol cessation, fluid and electrolyte correction, treatment of alcohol withdrawal, and pharmacological therapy based on the severity of the disease.
Merck's Combo Hepatitis C Treatment Effective in Drug Users
Study results presented at the 2015 Liver Meeting suggest that the investigational once-daily tablet elbasvir/grazoprevir can safely and effectively treat Hepatitis C virus in intravenous drug users, considered to be "difficult" cases, in part due to the risk of re-infection.
Morphine Regulator May Reduce Pain-Kill Abuse Risk
November 16th 2015Researchers appear to have identified a specific molecule that controls morphine receptor signaling in a small group of brain cells. The particular regulator of G protein signaling protein is called RGS7 and has been identified as a novel regulator of the μ-opioid receptor, which morphine acts upon to mediate its euphoric and analgesic effects.