In this series, Mark Lebwohl, MD, Saakshi Khattri, MD, Mona Shahriari, MD, and Jennifer Soung, MD, discuss various treatment options for moderate to severe plaque psoriasis, including topicals, oral therapies, phototherapy, and biologics. They emphasized the importance of considering patient preferences, comorbidities, and treatment history when choosing the appropriate therapy.

While topicals are often the first line of treatment, systemic therapy becomes an option for patients who fail topical treatment or achieve inadequate response. Biologics are considered effective and convenient, especially for patients who have not responded to other treatments or want to avoid psoriasis relapse cycles. Oral therapies are also discussed as an option for patients averse to injections, although biologics generally have better efficacy data. Shared decision-making between physicians and patients is highlighted as essential for tailoring treatment plans to individual needs and preferences. Additionally, the dermatologists note that even patients with mild psoriasis may require systemic therapy if their condition affects their quality of life or is refractory to topical treatments.

Video synopsis is AI-generated and reviewed by HCPLive® editorial staff.