Opinion

Video

Overview of Fibromyalgia

Philip J. Mease, MD, provides an overview of fibromyalgia as a primary disorder of central pain processing and modulation.

This is a video synopsis/summary of a panel discussion involving Philip J. Mease, MD.

Fibromyalgia, a central pain condition, manifests as heightened pain, fatigue, and cognitive dysfunction due to increased neurotransmitters in the central nervous system and a deficient inhibitory pathway. Prevalent in 2-4% of the general population, its association with chronic rheumatic diseases raises the incidence to 20%. Detection involves assessing patients with persistent pain, fatigue, and disproportionate symptoms. For instance, rheumatoid arthritis patients may experience pain despite normal inflammation markers. Advanced neuroimaging and spinal fluid analysis reveal changes in the central nervous system, including excessive nociceptive signaling and alterations in brain networks like the default mode network. Fibromyalgia sufferers lack rest in their central nervous system, exacerbated by factors like sleep disturbance and genetic predisposition. Understanding these complexities aids in managing fibromyalgia and its variations during stress or autoimmune inflammation flares. The medical community employs various diagnostic methods, including sophisticated neuroimaging and neurohormone testing, to comprehend and address the intricate nature of fibromyalgia.

Video synopsis is AI-generated and reviewed by HCPLive editorial staff.

Related Videos
John Stone, MD, MPH: Continuing Progress With IgG4-Related Disease Research
Philip Conaghan, MBBS, PhD: Investigating NT3 Inhibition for Improving Osteoarthritis
Rheumatologists Recognize the Need to Create Pediatric Enthesitis Scoring Tool
Presence of Diffuse Cutaneous Disease Linked to Worse HRQOL in Systematic Sclerosis
Alexei Grom, MD: Exploring Safer Treatment Options for Refractory Macrophage Activation Syndrome
Jack Arnold, MBBS, clinical research fellow, University of Leeds, Leeds Institute of Rheumatic and Musculoskeletal Medicine
John Tesser, MD, Adjunct Assistant Professor of Medicine, Midwestern University, and Arizona College of Osteopathic Medicine, and Lecturer, University of Arizona Health Sciences Center, and Arizona Arthritis & Rheumatology Associates
Gaith Noaiseh, MD: Nipocalimab Improves Disease Measures, Reduces Autoantibodies in Sjogren’s
Laure Gossec, MD, PhD: Informing Physician Treatment Choices for Psoriatic Arthritis
Søren Andreas Just, MD, PhD: Developing AI to Mitigate Rheumatologist Shortages for Disease Assessment
© 2024 MJH Life Sciences

All rights reserved.