Diana Do, MD
Vice Chair of Clinical Affairs
Professor of Ophthalmology
Byers Eye Institute
Stanford University School of Medicine
Palo Alto, CA
Perspectives on the Future of Retinal Disease Management
Experts conclude this series highlighting what is on the horizon of retinal disease care.
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Role of Tyrosine Kinase Inhibitors and Gene Therapy in Retinal Diseases
Experts discuss challenges in integrating gene therapy and port delivery systems early in treating common retinal diseases while emphasizing historical challenges and safety considerations.
Considering Safety of Gene Therapy for Retinal Diseases
Experts continue their discussion of gene therapy, highlighting safety concerns and the need for more trials and data.
The Status of Gene Therapy Development for Retinal Diseases
Experts shift to the prospect of gene therapy in treating retinal diseases.
The Impact of Biosimilars in Retinal Diseases
Experts discuss the use of biosimilars in treating neovascular age-related macular edema (nAMD) and diabetic macular edema (DME).
Safety Considerations for New Therapies
Experts discuss the safety of aflibercept 8 mg, emphasizing familiarity, efficacy, and durability, supported by reassuring data from the two-year PULSAR and PHOTON studies.
Perspectives on Loading Dose Recommendations for New Therapies
Experts discuss the practice of loading doses for newer agents and when they would consider this suitable for patients.
Perspectives on Retinal Fluid Management
Experts discuss the importance of fluid management, presenting a range of perspectives on managing complex cases.
Efficacy and Durability: New Therapies vs Aflibercept 2mg
Experts reflect on the current information available on the safety and durability of second-generation agents aflibercept 8 mg and faricimab.
Real-World Experiences With Aflibercept 8mg
Experts share their real-world experience with aflibercept 8 mg, comparing it to its predecessor, aflibercept 2 mg.
Real-World Experiences With Faricimab
Experts share their real-world experience with second-generation therapies, focusing on faricimab.
When to Switch to More Efficacious Agents
Experts discuss the timing of switching agents, particularly when switching to newer agents like aflibercept 8 mg or faricimab.
Choosing First-Line Therapy in nAMD or DME
Experts expand on the discussion of first-line therapy choice, discussing how insurance mandates may alter treatment paths and the importance of catering to patient goals.
Impact of First-Line Therapy on Long-Term Outcomes in nAMD and DME
Experts discuss the importance of optimizing first-line therapies in the treatment of retinal diseases like neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME).
Overview of nAMD and DME
Diana Do, MD, provides an overview of neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME).
Innovative Therapies on the Horizon to Treat AMD
Carl Regillo, MD and Diana Do, MD react to newer therapies being explored for wet AMD and discuss their place in future therapeutic algorithms.
Intravitreal Gene Therapy for Wet AMD
An overview of new gene therapy options for wet AMD that are currently being explored in clinical trials.
Faricimab: A New Bispecific Antibody with Promising Durability in AMD
Results of recent phase III clinical trials with respect to efficacy and safety of faricimab, an investigational bispecific antibody which inhibits both VEGF-A and angiopoietin-2.
Port Delivery System for AMD: Patient Selection and Safety Insights
Retina specialists provide insight into the patient selection and safety concerns with the innovative Port Delivery System (PDS) that offers a new means of sustained anti-VEGF therapy.
The Port Delivery System: A Novel Sustained Release Treatment Option in AMD
Carl Regillo, MD highlights the Port Delivery System (PDS), a new surgical implant with sustained release of anti-VEGF therapy that recently completed phase III clinical trials.
Brolucizumab Safety Signal: Impact on Practice
Carl Regillo, MD and Diana Do, MD discuss the safety concerns with the use of brolucizumab in wet AMD and the impact of these concerns in their practice.
Treat and Extend Approach to Anti-VEGF Therapy for AMD
An overview of standard anti-VEGF treatments for wet AMD and recommendations for individualizing patient therapy with a treat and extend approach.
Imaging Modalities in Wet AMD
Role of imaging modalities in the diagnosis and monitoring of age-related macular degeneration (AMD).
Differentiating Between Wet and Dry AMD
Carl Regillo, MD and Diana Do, MD, describe the progressive nature of age-related macular degeneration (AMD) and differences between dry AMD and wet AMD.