Considering Safety of Gene Therapy for Retinal Diseases

EP: 1.Impact of First-Line Therapy on Long-Term Outcomes in nAMD and DME

EP: 2.Choosing First-Line Therapy in nAMD or DME

EP: 3.When to Switch to More Efficacious Agents

EP: 4.Real-World Experiences With Faricimab

EP: 5.Real-World Experiences With Aflibercept 8mg

EP: 6.Efficacy and Durability: New Therapies vs Aflibercept 2mg

EP: 7.Perspectives on Retinal Fluid Management

EP: 8.Perspectives on Loading Dose Recommendations for New Therapies

EP: 9.Safety Considerations for New Therapies

EP: 10.The Impact of Biosimilars in Retinal Diseases

EP: 11.The Status of Gene Therapy Development for Retinal Diseases

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EP: 12.Considering Safety of Gene Therapy for Retinal Diseases

EP: 13.Role of Tyrosine Kinase Inhibitors and Gene Therapy in Retinal Diseases

EP: 14.Perspectives on the Future of Retinal Disease Management

Summary

Experts continue their discussion on the potential of gene therapy; in particular, they explore the exciting prospect of developing an ocular biofactory within a patient's eye to produce a VEGF inhibitor. Diana Do, MD expresses enthusiasm for gene therapy but raises a critical point about the long-term safety concerns of these specialized delivery systems. She emphasizes the inability to “turn off” gene therapy and highlights the need to understand the implications of chronic VEGF suppression within the eye over an extended period. David Eichenbaum, MD acknowledges the importance of addressing safety concerns associated with gene therapy, including inflammation and adverse events.

This summary was AI-generated and edited for clarity.