Prevalence of Cardiovascular Disease
November 27th 2024Panelists discuss how cardiovascular disease remains a leading health concern in the United States, examining its rising prevalence, risk factors such as dyslipidemia, and management strategies aligned with AHA guidelines to reduce patient mortality.
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Cardiometabolic Medicine: Seeing the Patient as a Whole
The panelists stress the significance of a comprehensive approach to patient care, acknowledging the interconnected nature of cardiovascular, kidney, endocrine, and obesity-related benefits, and highlighting that addressing secondary diseases can minimize overall disease risk in patients.
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Overcoming Prior Authorization Barriers in LDL Cholesterol Therapies
Michael Koren, MD addresses the challenges posed by prior authorization and the diminished role of pharmaceutical sales representatives in informing providers about medication advancements, leading to a disconnect in the provider's treatment arsenal.
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Medication Adherence in Patients with High LDL Cholesterol
The panel explores issues surrounding medication adherence and the potential for improved patient engagement. They emphasize that poor medication adherence increases the risk of cardiovascular events and discuss factors such as drug cost, timing of administration, and the importance of adopting a patient-centric approach to optimize treatment success.
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Diabetes, GLP-1, and Lipid Reduction
Michael Blaha, MD, highlights the potential of GLP-1 agonists in lowering LDL cholesterol, triglycerides, and body weight in patients with diabetes, presenting them as an additional option for reducing cardiovascular risk in this patient population.
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REDUCE-IT Trial and Triglyceride-Lowering Agents
The panel of medical experts addresses the challenges in raising awareness among healthcare providers about various medications and the need for increased awareness of the REDUCE-IT trial outcomes.
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Other Notable Emerging Lipid-Lowering Treatments
Erin Michos, MD, highlights several notable emerging lipid-lowering treatments, including bempedoic acid, the ANGPTL3 inhibitor evinacumab, the MTP inhibitor lomitapide, the ApoB-100 inhibitor mipomersen, and the ApoC-III degradation molecules volanesorsen and olezarsen.
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Examining Results from VICTORION-INITIATE Trial
Michael Koren, MD, discusses the recently released results from the VICTORIAN-INITIATE (V-INITIATE) trial, which were presented at the 2024 American College of Cardiology (ACC) Annual Scientific Session in Atlanta.
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Evaluating Safety of Novel LDL Management Mechanism
Deepak Bhatt, MD, MPH, MBA, reviews the efficacy and safety data of inclisiran, highlighting its long-term effects and noting that injection site reactions are among the most prominent adverse reactions associated with this medication.
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Optimizing PCSK9 Inhibitors and Analyzing Plaque Reduction Data
Michael Blaha, MD, discusses the efficacy and safety of novel targeted therapies for lowering LDL cholesterol and emphasizes the importance of long-term data in building patient confidence in this new treatment option.
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Innovations in Small Interfering RNA (siRNA) Therapy
Leading experts highlight the established role of PCSK9 inhibitors, such as evolocumab and alirocumab, and introduce the promising second-generation PCSK9 inhibitors, known as small interfering RNA (siRNA), which represent an innovative therapeutic approach that selectively reduces the production of specific proteins through RNA interference.
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Ongoing Lp(a) Trials and Clinical Approaches to Treatment
Panelists discuss ongoing clinical trials aimed at lowering Lipoprotein(a) levels, emphasizing the importance of proactive patient testing, and referring to new guidelines recommending that everyone be tested once in their lifetime.
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Stricter LDL-C Targets: Explaining Goalpost Changes to Patients
Key opinion leaders in cardiology share insights on reducing LDL cholesterol to manage cardiovascular disease risk, educating patients not reaching goals, and implementing real-world clinical strategies for maintaining lower LDL levels.
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Overview of Low-Density Lipoprotein Cholesterol Management
Erin Michos, MD, delivers a comprehensive review of lipid management and its influence on cardiovascular disease, emphasizing recent studies that underscore the need for improved treatment strategies for high-risk patients.
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Clinical Pearls on Lipid Management
A panel of expert cardiologists share their clinical pearls for managing patients with hyperlipidemia.
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Novel Targets for Lipid Level Lowering and Implementation of Lipid Therapy
Medical experts discuss the importance of screening for Lp(a) and ongoing trials targeting this protein. Moreover, other new targets for the treatment of hyperlipidemia are reviewed.
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The Role of Lipoprotein A in Lipid Lowering
Drs Michos, McGowan, and Kohli discuss Lp(a) and the development of cardiovascular disease.
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Long-term efficacy and safety of PCSK9 inhibitors
Drs Kohli and McGowan review recently published long-term efficacy and safety data on the use of a PCSK9-inhibitor.
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Nonstatin Lipid-Lowering Agents
Dr Michos discusses safety and efficacy of available nonstatin therapies and emerging agents for treating hyperlipidemia.
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Cardiologists discuss managing statin intolerance in clinical practice, highlighting the importance of creating individualized plans and when to initiate nonstatin therapies.
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Disparities in Managing Patients
Expert cardiologists discuss data on gender, racial, and ethnic disparities and how to address them in the management of hyperlipidemia.
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LDL Cholesterol as a Performance Measure
The cardiology panelists discuss the importance of screening patients for hyperlipidemia and familial hypercholesterolemia.
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Real-World Outcomes Data on Failure to Achieve LDL-C Thresholds
Mary McGowan, MD, FNLA, reviews real-world data from the Family Heart Database on the clinical consequences of failing to reach LDL-C thresholds.
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Real-World Data on Achieving LDL Thresholds
Mary McGowan, MD, FNLA, discusses real-world data from the Family Heart Database on achieving LDL-C thresholds.
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