Lana Pine

A proportion of patients reported triggering or worsening symptoms after a meal, with the largest proportion experiencing bloating or distention, followed by abdominal pain or discomfort, and epigastric pain.

No statistically significant differences in infusion reaction, serious reaction, or immunogenicity rates were identified between patients switching to an infliximab biosimilar and those who continued treatment on the originator.

No statically significant differences in ESR, CRP, TNF levels, and albumin were observed pre- and post-switch from the infliximab originator to the biosimilar.

At the 12-month mark, 52% of patients in the axSpA cohort and 76% of those in the IBD cohort achieved clinical remission.

Clinical outcomes of lab values were not statistically different in changes from baseline to 12 months between children with inflammatory bowel disease initiated on the TNF originator or biosimilar.

Results highlight the need for physicians to consider rheumatoid arthritis in patients with microscopic colitis presenting with arthralgia or other joint symptoms.

Chronic tophaceous gout was demonstrated to be an independent risk factor linked to the development of colorectal cancer.

A maternal rheumatoid arthritis (RA) diagnosis before delivery was linked to an increased risk of offspring with autism spectrum disorder, particularly for those with seronegative RA.

The use of traditional Chinese medicine had a statistically significant association with improved clinical indicators in patients with rheumatoid arthritis.

A Cox regression analysis showed a significant association between a gout diagnosis and subsequent breast cancer diagnosis in the total population.

Themes related to coping with fibromyalgia included emotional coping, practical coping, and coping with the social environment.

Most patients remained on infliximab biosimilars during the follow-up period and the number of switches was not independently linked to infliximab persistence after adjusting for confounders.

In patients with fibromyalgia, vitamin D supplementation improved physical function, and role limitations due to emotional health, general health, and social function.

The biosimilars month in review highlights the positive safety and efficacy data of 3 biosimilars used to treat rheumatic diseases, gastroenterologists discuss the risks and benefits of prescribing biosimilars to their patients, and physicians emphasize the importance of patient education.

The April 2023 rheumatology month in review highlights recent data regarding physical activity levels among patients with JIA, a link between fibromyalgia and psychiatric disorders, and a feature focused on the treatment of polymyalgia rheumatica.

The Inflation Reduction Act contains a provision that boosts reimbursement to physicians to encourage the adoption of biosimilars and allows biosimilars to have lower list prices, benefiting patients' out-of-pocket costs.

As previous studies have shown slow uptake of biosimilars, Ross Maltz, MD, and his team wanted to get a better understanding of this issue using a survey focused on pediatric gastroenterologists.

Patients receiving tocilizumab and LZM008 showed comparable pharmacokinetic properties after a single intravenous dose.

GPX3, an antioxidant enzyme and reactive oxygen species scavenger, was categorized as a hub gene in rheumatoid arthritis neutrophils.

The serum glycated hemoglobin levels and the incidence of thyroid cancer in patients with type 2 diabetes in patients with type 2 diabetes were significantly higher in the observation group when compared with the control group.

Compared with those without SLE, those with SLE had a higher risk of fetal morbidity and mothers were almost 4 times as likely to require a blood transfusion or develop a cerebrovascular disorder.

At week 54, there were no significant differences in patients achieving the target exposure (5 µg/mL) between those in the monotherapy cohort and those in the combination therapy cohort.

While age and fat mass were inversely associated with cardiorespiratory fitness (CRF), the physical activity index was positively associated with CRF.

Among pediatric gastroenterologists surveyed, most were comfortable prescribing an infliximab biosimilar to patients who were tumor necrosis factor (TNF)-naïve and switching to a biosimilar for those in clinical remission.

Patients with fibromyalgia receiving the synbiotic intervention reported decreased levels of anxiety, depression, and stress, as well as improvements in quality of life during daily activities.

Women with rheumatoid arthritis (RA) in remission exhibited higher values of Disease Activity Score-28 for Rheumatoid Arthritis with erythrocyte sedimentation rate (DAS28-ESR) compared with men.

Between 2011 and 2018, age- and sex-adjusted prevalence among Asian Americans doubled from 3.3% to 6.6%, which exceeded all other ethnic and racial groups.

At month 6, 71.0% in the smart system of disease management group achieved a DAS28-CRP of 3.2 or less compared with 64.5% in the control group.

A negative relationship between bone mineral density (BMD) and hyperuricemia in total, as well as in the L1, L2, and L3 lumbar vertebrae, was demonstrated in the multivariable-adjusted regression models.

Patients with intercritical gout had higher CXCL12 levels, IL-18, and IL-1β when compared with controls.