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Procainamide-induced Pleural and Pericardial EffusionsDrug-induced diseases and serious adverse drug effects can alter therapeutic plans and greatly affect patient outcomes. Many medications are known to have a narrow therapeutic index and to require close patient monitoring.
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Treating Breast Cancer in Pregnancy Affords a Survival AdvantageAn abstract presented at 2010 Breast Cancer Symposium analyzed pregnant women with breast cancer.
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Antiplatelet and anticoagulant therapy in patients with atrial fibrillationWe investigated 1209 patients with valvular and nonvalvular atrial fibrillation who were treated with standard anticoagulant therapy, the cyclooxygenase inhibitor triflusal, or combined therapy with triflusal and an anticoagulant. Compared with patients receiving standard anticoagulation treatment, the addition of antiplatelet therapy to reduced-intensity anticoagulation in patients stratified for risk of stroke significantly reduced the vascular event rate.
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Executive Function Disorder and ADHDExecutive function disorder and ADHD share several overlapping symptoms, and the presence of executive function impairment is often associated with a diagnosis of ADHD. Clinicians should be aware of the testing modalities that can help accurately identify executive function disorder, and also be aware of the limitations of current medications when it comes to mitigating symptoms.
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6 Ways Oncologists and Dermatologists Can Work Together to Improve Cancer CareCollaboration between dermatologists and oncologists is crucial.
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Analysis of regional left ventricular functionWe performed cineventriculography, unenhanced echocardiography, contrast-enhanced echocardiography, and magnetic resonance imaging to define the presence of regional left ventricular wall motion abnormalities. Interobserver agreement in the analysis of regional wall motion abnormality was highest for contrast-enhanced echocardiography, followed by cineventriculography and cardiac magnetic resonance imaging; it was lowest for unenhanced echocardiography. Contrast-enhanced echocardiography also showed the highest accuracy in the detection of panel-defined regional wall motion abnormalities.
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Considerations for Duration of DAPT in Patients With DiabetesThe optimal duration of dual antiplatelet therapy remains unclear, despite being proven efficacious for roughly 2 decades.
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The "Team" Behind Docs That Helps Deliver the Best ResultsAI tools and health tech can be used to help the healthcare system treat patients.
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Do You Have the Right Tools?: How IT adoption can enhance your practiceTrue integration of cutting-edge care and timely translation of information from the bench to bedside requires an oncology practice to have knowledgeable physicians and a "toolbox of technology."
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Could Saturated Fat Be Good for the Heart?Current dietary guidelines promoting high consumption of polyunsaturated fatty acids and low consumption of total saturated fats are not clearly supported by the medical literature.
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NOW Initiative: Payer & Provider Collaborations in Oncology Benefits ManagementPayers recognize the need to expand benefits management for oncology but struggle to find effective solutions amid the complexity of available therapies and skepticism from oncologists, who are facing their own set of economic pressures. The National Oncology Working Group (NOW) Initiative is trying to change the sometimes adversarial relationship between payers and oncologists through a collaborative model.
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ARO-HBV Reduces All Measurable Viral Products in Patients with Chronic Hepatitis B Virus InfectionThe first results of a study on the use of monthly RNAi with ARO-HBV in patients with chronic hepatitis B virus infections indicate that the treatment effectively reduced all measurable viral products, including HBsAg.
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Useless Medical DevicesThroughout history, the public's pursuit of good health has, in the absence of scientific method or even common sense, motivated the creation of some downright ridiculous medical devices.
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Chest pain syndrome in women: A diagnostic dilemmaThe ability to diagnose coronary artery disease (CAD) in women may be limited by the sensitivity and specificity of symptoms as well as of noninvasive testing. The choice of which test should be performed to evaluate the presence of CAD in women remains controversial. Currently American Heart Association/American College of Cardiology guidelines recommend initial evaluation with exercise electrocardiogram (ECG) testing. In a meta-analysis of 3721 women, however, exercise ECG had a sensitivity of 61% and a specificity of 70%1 as compared to 68% sensitivity and 77% specificity in men.
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Renal dysfunction in older age groups and mortality after acute myocardial infarctionOnly one third of patients admitted to the hospital with acute myocardial infarction have normal renal function, and 17% have severe renal impairment. Decreased renal function is associated with the presence of comorbid conditions, underuse of effective treatments, and higher mortality. Renal function parameters should not only be included in scoring systems to assess risk levels, but patients with abnormal renal function should benefit from careful application of guidelines-recommended treatments for acute and long-term care.
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How to Pick & Choose: Which Patient & Agent in Biologic-Naive PatientsThe past decade has seen increased use of TNF antagonists for the treatment of inflammatory bowel disease.
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Reactivation of Hepatitis B Associated With Immunosuppressive MedicationsIn patients with chronic HBV, the immune system may have very low levels of the virus. When reactivation occurs due to immunosuppression, these viruses begin to replicate again. Common symptoms of this event include inflammation of the liver and elevations of liver enzyme levels in the blood. In some cases, bilirubin levels may rise in response to reactivation of infection.
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C-Reactive Protein: A New Tool for Cardiovascular Disease Risk PredictionRecent research into the use of markers of inflammation to aid in cardiovascular risk assessment has focused on C-reactive protein, an acute-phase reactant found in atherosclerotic lesions. Serum levels of C-reactive protein are strongly associated with cardiovascular disease risk. Several clinical trials have shown that elevated C-reactive protein concentration predicts increased risk in persons with average or even below-normal levels of low-density lipoprotein cholesterol. When measured with the high-sensitivity assay, C-reactive protein has been shown to add to the predictive power of traditional cardiovascular risk factors and can enhance the 10-year Framingham Risk Score risk prediction. This article reviews the available evidence and addresses the potential for lowering C-reactive protein levels to reduce the risk of cardiovascular disease.
