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Are HDL cholesterol levels clinically significant in patients with low LDL cholesterol levels?There is some debate about whether the risk of cardiovascular events associated with low high-density lipoprotein (HDL) cholesterol levels is attenuated by very low low-density lipoprotein (LDL) cholesterol levels (< 60 mg/dL), which can be obtained with statins and combination therapy.
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PCI Versus CABG in Patients with Left Main CADChoosing the revascularization strategy is a complex decision for the Heart Team and patient.
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Undiagnosed diabetes mellitus in coronary artery bypass graft surgeryWe examined the prevalence and risks associated with undiagnosed diabetes mellitus among more than 7000 patients who had undergone coronary artery bypass graft surgery. At the perioperative and postoperative stages, patients with undiagnosed diabetes showed a significantly higher morbidity and mortality rate.
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Apple is Actively Recruiting Healthcare Providers at their Retail StoresApple recently held a workshop designed for healthcare professionals to learn more about medical apps, how to use them, and where to get them.
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Adding Topiramate to the Obesity Treatment ToolboxAs the prevalence of overweight and obese patients continues to surge, an efficacious pharmacological treatment for obesity is desperately needed in everyday clinical practice.
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Non–ST-segment elevation ACS: Should all patients undergo cardiac catheterization?We performed a systematic review and meta-analysis of all clinical trials comparing routine invasive strategy with selective invasive strategy in patients with non–ST-segment elevation acute coronary syndrome. We did not find either strategy to offer an advantage over the other, even when we excluded trials that did not use coronary stents and glycoprotein IIb/IIIa inhibitors.
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Does Sodium Restriction Improve Cardiovascular Outcomes?Dietary sodium restriction is frequently recommended as a means to manage hypertension, congestive heart failure and cardiovascular disease. However, with the growing focus on patient-centered outcomes rather than disease-centered outcomes, the importance of sodium restriction becomes less clear.
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Effectiveness and Cost-Effectiveness of Diabetes Prevention among Adherent ParticipantsOver 10 years, lifestyle intervention and metformin were cost-effective or cost saving compared with placebo.
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Novel Treatment for Refractory Angina Using a Coronary Sinus Reducer Device: A Glimmer of HopeRefractory angina is a loosely defined term generally referring to the persistence of life-impacting angina despite maximal antianginal medications and, when possible, coronary revascularization (percutaneous coronary intervention [PCI] or coronary artery bypass grafting [CABG]). Numerous novel pharmacotherapies and mechanical interventions have been proposed, and studies conducted, to treat patients with refractory angina.
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Knocking on Winter's DoorIn this issue of Cardiology Review, we cover a wide variety of topics while saying hello to the winter of 2014.
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Presidential Candidates on Health Care Issues: Bernie SandersPart of an ongoing series that takes a high-level look at the positions of the leading nominees for President when it comes to political issues potentially impacting physicians, this installment focuses on Bernie Sanders.
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Achieving Meaningful Use: A Health System PerspectiveThe experience of Partners HealthCare offers some unique insights into the process of electronic medical record adoption across a large, diverse health system.
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High clopidogrel maintenance dosage in patients with diabetes mellitus and coronary artery diseasePatients with type 2 diabetes mellitus have decreased platelet inhibition and decreased responsiveness to standard doses of clopidogrel compared with patients without diabetes. In this pilot study, we showed that increasing the maintenance dose of clopidogrel to 150 mg leads to enhanced platelet inhibition compared with the standard dose of 75 mg in patients with type 2 diabetes with suboptimal responsiveness. The clinical implications of these findings are unknown, however, and need to be evaluated in large-scale clinical trials.
