Asthma

Investigators defined AHR as “a hallmark of persistent asthma”, noting that it could also be assessed via indirect challenge with mannitol.

In particular, airway epithelial cells (AEC) in allergic asthmatic (AA) were shown to upregulate mucus metaplasia, matrix-remodeling, and glycolytic programs while failing to upregulate antioxidant genes.

Results from the 2 APPaRENT trials suggest regular inhaled corticosteroids/LABA alone or with short-acting beta agonists were the preferred treatment approach with physicians.

Dr. Lugogo explains how the ProAir Digihaler was used to accurately monitor SABA use in patients with asthma -many of whom were overusing their medication- which could allow clinicians to make appropriate changes to treatment.

Elliot Israel, MD, and Juan Carlos Cardet, MD, MPH, join Lungcast to discuss their latest research into addressing Black and Latinx asthma outcome disparities.

Research has indicated that a fixed-dose combination of albuterol and budesonide could better reduce the risk of severe asthma exacerbation when compared to albuterol alone.

The 2022 State of the Air report from the American Lung Association highlights growing disparities in coastal-based ozone and particle pollution, amid wildfires and shifts in regulatory policies.

The inhaler is approved for 2 strengths, 160/4.5 mcg/actuation and 80/4.5 mcg/actuation.

Investigators noted that the epidemiology and disease overlap among eosinophilic diseases are poorly understood.

The reductions were seen as early as week 2 and was sustained throughout the 52 week study.

By blocking certain neurogenic changes that occur in the lungs at childhood, patients may avoid asthma and allergic responses into adulthood.

The study found that PARTICS, in addition to the usual care these patients received, reduced severe asthma exacerbations by 15.4% (p50.048) which corresponded to a reduction of 13 exacerbations/100 patient-years.

Patients with allergic asthma could often have no clinical history of atopic dermatitis.

Knowledge on distinguishing moderate and severe eczema increased the most after the video training.

Dr. McKeon speaks of how patients can be more involved with managing their asthma and allergies by avoiding exposures in their own homes.

Though telemedicine has improved upon school-based asthma programs across the country, Dr. Phipatanakul notes that the adoption of these programs can be difficult to implement.

Dr. Trivedi speaks of a new text-based program that helps provide asthma care to children from communities of color, as well as how COVID-19 affected school-based asthma programs.

Dr. Zein speaks of the relationship between eosinophil count and COVID-19 illness and mortality, especially as it related to inhaled corticosteroid use.

The American College of Allergy, Asthma, and Immunology identify key practices for addressing allergies during the COVID-19 pandemic.

The esteemed pediatric pulmonologist of Bridge Atlanta Medical Center drops by Lungcast to discuss the disparities that continue to exist in childhood asthma.

Patients with asthma and bronchiectasis were more likely to have chronic rhinosinusitis than patients without bronchiectasis, according to investigators.

Previous contrasting studies found that omalizumab was less effective in reducing exacerbations in obese patients.

New data from the NAVIGATOR study found that tezepelumab was associated with fewer asthma exacerbations throughout all seasons of the year compared to placebo.

Dr. Shrine and colleagues conducted the largest genome-wide association study of coexisting asthma and COPD to date in a 2-stage design incorporating a total of 13 studies.

A better understanding of this connection could yield preventative treatments.

The institute will assemble and support a diverse, multidisciplinary team of scientists and researchers to lead the charge breakthroughs in airway science.

Patients with asthma were at increased risk of hospitalization and ICU admission or death, prompting investigators to suggest these patients be considered a priority group for booster COVID-19 vaccines.

Patients with severe eosinophilic asthma who stopped treatment also experienced reduced asthma control and shorter times for clinically significant exacerbations.

More than 70% of parents of children with asthma said they in favor of the influenza vaccine during the COVID-19 pandemic.

Investigators concluded that long-term data are needed regarding surgery, but confirmed it to be more efficacious than medical therapy alone.