The HCPLive Cardiology condition center page is a comprehensive resource for clinical news and insights on cardiovascular and cardiometabolic diseases. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for heart disease and cardiovascular events, as well as associated diabetes, renal failure, and more...
September 19th 2024
EDG-7500 was well-tolerated in healthy patients in Phase 1 while achieving gradient relief without LVEF reductions in the Phase 2 CIRRUS-HCM trial.
September 12th 2024
September 10th 2024
Elevating Care for PAH: Applying Recommended Management Approaches to Maximize Outcomes
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‘REEL’ Time Patient Counseling™: Navigating the Complex Journey of Diagnosing and Managing Fabry Disease
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Expert Illustrations & Commentaries™: Envisioning Novel Therapeutic Approaches to Managing ANCA-associated Vasculitis
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An elderly woman taking amiodarone and warfarin to prevent reccurrence of atrial fibrillation
November 4th 2008An 80-year-old woman with hypertension, diabetes, and osteoarthritis experienced an episode of atrial fibrillation 1 year earlier, causing presyncope accompanied by palpitations, but no other symptoms.
Metformin May Be Linked to Lower Risk of Death from Cardiovascular Disease
A meta-analysis of 40 previously published studies conducted by Elizabeth Selvin, PhD, MPH, of the Johns Hopkins Bloomberg School of Public Health, and colleagues has found that treatment with the diabetes drug metformin may be associated with a lower risk of death from cardiovascular disease.
Early invasive or selective invasive strategies for ACS patients
October 22nd 2008Treatment of stable patients with acute coronary syndrome (ACS) is controversial. Until recently, large randomized clinical trials had indicated that an "early" invasive strategy with routine cardiac catheterization reduced the likelihood of recurrent cardiovascular events when compared with a more "selective" approach, in which stable patients were referred to cardiac catheterization based on high-risk features on noninvasive stress imaging or because of a failure in initial medical therapy.
Incidence of death and MI associated with stopping clopidogrel after ACS
October 21st 2008Rates of death and myocardial infarction were assessed for a national sample of acute coronary syndrome patients after stopping clopidogrel. In the first 90 days after stopping treatment, patients experienced a nearly twofold increased risk of adverse events compared with subsequent follow-up intervals for patients treated medically without stents and for patients treated with coronary stents. This suggests a possible clopidogrel rebound effect, but additional studies are needed to support this hypothesis and to identify strategies to reduce early events after clopidogrel cessation.
Non–ST-segment elevation ACS: Should all patients undergo cardiac catheterization?
We performed a systematic review and meta-analysis of all clinical trials comparing routine invasive strategy with selective invasive strategy in patients with non–ST-segment elevation acute coronary syndrome. We did not find either strategy to offer an advantage over the other, even when we excluded trials that did not use coronary stents and glycoprotein IIb/IIIa inhibitors.
Intensive glycemic control has no effect on cardiovascular disease in type 2 diabetes
October 16th 2008The benefits of intensive glycemic control appear to be confined to microvascular disease, with 3 randomized controlled clinical trials failing to demonstrate a macrovascular benefit with intensive glycemic control in patients with type 2 diabetes.
Direct renin inhibition in the elderly
Hypertension may well be the most important public health issue facing society today.