Endocrinology

Results from a new pilot study show early lifestyle intervention in obese pregnant women cuts their risk of developing gestational diabetes, as well as maternal and fetal complications that can emerge with high blood sugar.

Landmark study results presented at ACC.13 reveal patients with vascular disease treated with niacin therapy face increased risk of myopathy and other adverse events.

Though the causes of acute pancreatitis are unknown in roughly a quarter of its worldwide patient population, a recent analysis published in JAMA Internal Medicine has discovered a link between increased risk of the disease and medicines containing cortisone.

Many widely held beliefs about obesity and weight loss have no scientific basis.

The American Diabetes Association revised Standards of Medical Care for patients with diabetes include several changes in recommendations regarding testing and treatment goals.

Brief summaries of research results and other articles on the clinical characteristics, evaluation, and management of patients with hyponatremia.

The FDA has approved cabozantinib, a multi-targeted tyrosine kinase inhibitor, for the treatment of metastatic medullary thyroid cancer.

Although hormonal therapy has been long established in the treatment of breast cancer, novel combinations with targeted agents show promise for improved outcomes and are likely to become part of a new paradigm for managing patients.

Hospitalized patients with cirrhosis who also have hyponatremia often receive no treatment, or ineffective treatment, and are often discharged with their serum sodium too low.

Study results presented at The Liver Meeting (AASLD 2012 annual meeting) show that consuming small amounts of alcohol can have net positive cardiovascular health benefits for some patients with non-alcoholic fatty liver disease.

Boceprevir and telaprevir offer improved clinical benefits to patients with hepatitis C, but a variety of racial, genetic, and other biological factors can influence treatment outcomes.

Study results presented at The Liver Meeting (2012 AASLD annual meeting) show that treatment with tenofovir disoproxil difumarate is safe and effective in this patient population.

Results from the RELAX-AHF show serelaxin reduces cardiovascular deaths and improves symptoms in patients with heart failure.

Results from a substudy of the PLATO trial show that patients with extensive CAD and high rates of recurrent cardiovascular events, death, and bleeding may benefit from treatment with ticagrelor.

Results from the UMPIRE study show that use of fixed-dose combination cardiovascular drugs improve medication adherence and improve blood pressure and cholesterol levels in patients.

Study results presented at AHA 2012 indicate that revascularization using CABG in diabetic patients with multivessel disease provides better clinical outcomes than PCI and is more cost effective in the long run.

Results from a sub-study of the Trial to Assess Chelation Therapy (TACT) that focused on quality of life issues in patients who had previously suffered a heart attack and were treated with chelation therapy reveal no improvements in these patients' quality of life.

Randomized controlled trials remain the gold standard, but a researcher at Kidney Week 2012 says that new approaches and study designs are needed that reflect real-world drug use and account for confounding variables.

Patients with end-stage renal disease who live in the Midwest begin dialysis at an earlier stage than patients who live in other regions of the US.

Results from the TEMPO trial presented at Kidney Week 2012 show that treatment with tolvaptan slowed the increase in total kidney volume and the decline in kidney function in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD).

Increasing numbers of people are on kidney transplant waiting lists. However, the number of potential living donors may shrink as more Americans qualify as pre-diabetic, making them less than ideal donor candidates.

Experts at Kidney Week 2012 discuss several treatment options for hyponatremia, including fluid restriction, loop diuretics, and the use of selective vasopressin V2-receptor antagonists.

A diet rich in highly alkaline fruits and vegetables helps reduce a marker of kidney injury and preserve kidney function in patients with chronic kidney disease.

The powerful immunosuppressive drugs used to prevent allograft rejection are associated with severe side effects. A "mixed chimerism" strategy in which patients undergo simultaneous bone marrow and kidney transplant from the same donor may improve transplant survival and reduce the need for these drugs.

Use of peritoneal dialysis in patients with end-stage renal disease is declining due to lack of physician training and awareness, financial disincentives, and other factors. However, with proper patient and provider education, it is possible to grow a successful peritoneal dialysis program.

Study results reported at Kidney Week 2012 reveal that patients with early-stage CKD fare better in the public health system, which also appears to produce fewer racial and ethnic health disparities in care delivered to this population.

Consuming 200 milligrams or more of caffeine per day-roughly equivalent to two cups of coffee-can either increase or decrease a woman's estrogen level, depending on her ethnic background and the source of the caffeine, a study from the National Institutes of Health (NIH) finds.

The US Food and Drug Administration has approved Jentadueto, a type 2 diabetes treatment that combines two drugs (linagliptin and metformin) in a single pill.

Consumption of sugar, which helps to drive the obesity crisis and causes millions of deaths worldwide each year, should be controlled like other threats to public health, a team of researchers from the University of California San Francisco argue in the Feb. 2 issue of Nature.

Poor sleep is connected to a significantly increased risk for major cardiovascular and metabolic disorders, such as obesity, diabetes, and coronary artery disease, researchers at the University of Pennsylvania's Perelman School of Medicine have found.