December 20th 2024
A study finds that individuals with low or high LDL cholesterol levels face a greater cardiovascular risk than those with medium levels.
December 15th 2024
Real-world data from 18,710 MASH patients highlight the impact of comorbidities, biomarkers, and region on mortality, with 70% of deaths CVD-related.
December 14th 2024
Observational data point to aldosterone dysregulation as an underrecognized risk factor for hypertension and confirm T2D as a known risk factor.
December 12th 2024
Patients with hypercortisolism and difficult-to-control type 2 diabetes who received mifepristone exhibited a significant HbA1c improvement in the Phase 4 trial.
Elevated blood insulin levels and insulin resistance each contributed to an elevated risk of colorectal cancer, a new study finds.
GLP-1 Receptor Agonists Could Reduce Stroke Risk in Type 2 Diabetes
A propensity score-matched study from ASH 2024 suggests GLP-1 RA use reduced VTE risk in type 2 diabetes.
A Pillared Approach: A Suite of Therapies for a Spectrum of Metabolic Disease
A look into how SGLT2 inhibitors, GLP-1 RAs, and nsMRAs have redefined the management of cardio-kidney-metabolic diseases.
SURMOUNT-5: Tirzepatide Bests Semaglutide in Head-to-Head Weight Loss Trial
Data from SURMOUNT-5, a head-to-head trial, demonstrate tirzepatide offered greater weight loss benefits than semaglutide.
Endoscopy in the Age of GLP-1 RAs: 2024 Sees New Risk-Based Perioperative Guidance
Previous ASA guidance recommended holding GLP-1 RAs in the perioperative period, but new 2024 multisociety guidance suggests a risk-based approach.
Endocrinology Month in Review: November 2024
Our Endocrinology Month in Review for November 2024 highlights recent headlines in diabetes and endocrinology as well as 5 new episodes of Diabetes Dialogue.
Obesity Drug MariTide Achieves Up to 20% Weight Loss in Phase 2 Trial
Amgen’s MariTide achieved up to 20% average weight loss at 52 weeks without hitting a plateau in individuals with obesity or overweight.
More than 50% of US Adults Considered Eligible for Semaglutide with Current Labeling
More than half of US adults—approximately 137 million—are candidates for semaglutide based on diabetes, weight management, or cardiovascular prevention indications.
Intensive Blood Pressure Regimen Lowers CVD Risk in People with T2D
Reducing systolic blood pressure to less than 120 mmHg lowered the risk of major cardiovascular events for most people with diabetes in the BPROAD trial.
Understanding the Effects of nsMRA vs MRA
In part 2 of this 5-part series, Lerma and Lala-Trindade discuss the key differences in MoA for nsMRA and MRAs.
Exploring the Interplay Between Chronic Kidney Disease and Cardiovascular Disease
In this first of this 5-part series, Lerma and Lala-Trindade discuss the interplay between chronic kidney disease and cardiovascular disease.
10-Year Follow-Up Shows Lasting Benefits of Bariatric Surgery for Teens with Severe Obesity
A decade after bariatric surgery, most teens maintained weight loss and reduced obesity-related conditions such as type 2 diabetes and hypertension.
Richard Pratley, MD: FLOW Mortality Data and Allocation Strategies for Semaglutide
Richard Pratley, MD, discusses how FLOW mortality data informs the use of semaglutide in patients with chronic kidney disease and type 2 diabetes.
Oral Semaglutide Reduces MACE Risk in People With Type 2 Diabetes and CVD
Novo Nordisk will present more detailed data in 2025 and plans to file for an expanded label for Rybelsus for this population.
SGLT2i Outperforms DPP4i in Improving Hepatic Fibrosis Indices in MASLD
SGLT2 inhibitors appeared effective in improving hepatic inflammation and fibrosis indices in patients with type 2 diabetes and suspected MASLD.
Endocrinology Month in Review: September 2024
Our September 2024 monthly recap in endocrinology spotlights regulatory updates, new guidelines, and the latest episodes of Diabetes Dialogue.
Ertugliflozin Lowers UA, Improves Gout Outcomes in People With Type 2 Diabetes and ASCVD
There were no differences in the treatment effect of ertugliflozin on gout-related outcomes in subgroups based on eric acid quintile or other baseline characteristics.
FDA Clears Eversense 365, Marking First 1-Year CGM Option in Diabetes
The FDA has approved the Eversense 365, the world’s first 1-year continuous glucose monitor, with US availability expected in late 2024.
GLP-1 RA Linked to Lower Risk of Cirrhosis Development in Patients with MASLD
A new study found glucagon-like peptide 1 receptor agonist use was associated with a lower risk of cirrhosis complications for patients with MASLD who did not have cirrhosis.
Endocrinology Month in Review: August 2024
The endocrinology month in review for August 2024 spotlights 6 pieces of major pipeline news or regulatory announcements as well as multiple episodes of Diabetes Dialogue.
Brendon Neuen, MBBS, PhD: Expanding Evidence of Combination Therapy with GLP-1 RAs and SGLT2 Inhibitors
A meta-analysis shows GLP-1 RAs and SGLT2 inhibitors offer distinct cardiovascular and kidney benefits in type 2 diabetes.
Rahul Aggarwal, MD: Sotagliflozin Benefit Grows with Increasing Diabetes Duration
Rahul Aggarwal, MD, discusses the findings of a SCORED analysis examining sotagliflozin's effects based on diabetes duration.
Study Finds Diabetes Complications and Mental Health Disorders Are a 2-Way Street
Michigan Medicine and U-M research finds a bidirectional link between mental health disorders and chronic diabetes complications, urging comprehensive screenings.
Diabetes Dialogue: Stelo OTC Availability and Omnipod 5 for Type 2 Diabetes
In this episode, hosts discuss the implications of Dexcom announcing availability of their Stelo sensor and the FDA clearance of the Omnipod 5 for type 2 diabetes.
FDA Clears Omnipod 5 AID System for Type 2 Diabetes
FDA expands Omnipod 5 AID system for type 2 diabetes, marking the first AID system approved for both type 1 and type 2 diabetes management.
Dexcom Announces Availability, Pricing of Stelo—First OTC Glucose Sensor
Dexcom's Stelo, the first OTC glucose sensor, launches in the US on August 26, 2024, offering 15-day wear and HSA/FSA eligibility for as low as $89.99 per 2-pack.
Semaglutide Linked to Suicidal Ideation, New Study Reveals
A new study significantly demonstrated semaglutide, but not liraglutide, is associated with suicidal ideation.
Diabetes Dialogue: Sotagliflozin for T1D and Other ADCES 2024 Highlights
This episode focuses on sotagliflozin in type 1 diabetes and other highlights from the ADCES 2024 annual meeting.
Diabetes Dialogue: First 10 Prices Announced from CMS Price Negotiations
In this episode, hosts react to the announced CMS list prices for the first 10 drugs chosen for negotiation as part of the Inflation Reduction Act.
HbA1c Highly Predicts NAFLD Disease Severity
A new analysis suggests HbA1c may be more informative to fatty liver disease severity than BMI, and should be included in screenings.
Diabetes Dialogue: Navigating ADCES 2024
The first of 2 episodes on ADCES 2024, this episode focuses on sessions and presentations hosts Isaacs and Bellini participated in during the meeting.