Endocrinology

Researchers in Australia recently reported that the immune signaling protein NLRP1 plays a key role in metabolism by activating fat-burning processes when the body's energy intake is too high.

A clinical trial with a choline-rich structured lipid found that daily intake can significantly reduce choline depletion in cystic fibrosis patients with exocrine pancreatic insufficiency.

There are approximately 500,000 new cases of heart disease every year, and with heart failure being a potential complication in many of those cases, effective therapies are necessary.

Hyperkalemia can be fatal and there is a serious need to provide improved treatment options.

Study results show asthma severity can be controlled with weight loss in obese patients.

Non-diabetic obese patients experienced many benefits from taking a GLP-1 agonist.

At the 2015 Cardiometabolic Health Congress, Christie M. Ballantyne, MD, moderated a panel discussion focusing on current cholesterol guidelines and several changes that may be coming soon.

Lipid resuscitation therapy was identified in 1998 as an effective treatment for local anesthetic systemic toxicity. Since then, researchers have developed a better understanding of the risk factors involved and the manner in which lipids work, using both dynamic scavenging and direct cardiotonic effects.

Elevated levels of triglycerides have been proven time and time again to be linked to cardiovascular disease. While it can be a challenging condition to control, it opens the door for treatments.

It wasn't long ago that researchers first identified a piece of DNA that regulates cholesterol. This gene has been recently developed into a cholesterol-lowering agent and it's time to address where we go from here.

Type 1 diabetes mellitus (T1DM) is treated by necessity with insulin analogues in an attempt to mimic normal physiological insulin profiles. Regardless, this approach is rarely completely successful and most T1DM patients experience fluctuating or suboptimal glucose control, significant hypoglycemia and microvascular tissue complications.

Most adults in developed nations struggle with their weight. Ample quantities of high-quality foods (and plenty of sugar- and fat-laden snacks) do more than just nourish us. They allow us to overindulge; in fact, they tend to make people eat mindlessly.

What effect did GLP-1 agonists have on brain glucose metabolism?

It's a constant question of whether physician decision making has benefitted the patients or not.

Cystic dilatation of the bile duct (usually called choledochal cyst)-is a rare condition that causes numerous complications, such as chronic pancreatitis, which is the most common cause of exocrine pancreatice insufficiency in adults.

Our Oct. list of endocrinology news & research includes conflicting opinions on the obesity paradox and self-harm issues after bariatric surgery.

Positive hepatitis C infection may increase risk for liver damage as well as future heart problems, according to findings published in The Journal of Infectious Diseases.

Though it is still in development, a blood test may be able to detect pancreatic cancer in early stages, according to a proof of concept study published in Cancer Prevention Research.

Treatment-experienced patients with HIV who switched to a tenofovir alafenamide-based treatment regimen maintained excellent virologic suppression while exhibiting significant improvements in both bone and renal safety.

Patients who are morbidly obese need a revised dosing protocol when getting vancomycin.

The US Food and Drug Administration requested three manufacturers of duodenoscopes – Olympus America, Inc. Fujifilm Medical Systems, USA, Inc., and Hoya Corp – to perform real-world postmarket surveillance studies duodenoscopes used to perform endoscopic retrograde cholangiopancreatography procedures (ERCP).

The "obesity paradox" suggests that patients with excess weight are associated with better survival among individuals with cardiovascular disease -a mysterious and confounding phenomenon that has been demonstrated in many clinical studies.

Cardiac complications with diabetes and the effects of bariatric surgery on diabetes control are discussed in the following slides.

The International Working Group on the Diabetic Foot (IWGDF) Guidance 2015 recently published its evidence-based international consensus guidance. This guideline addresses 5 specific areas of concern in diabetes.

Resistance to thyroid hormone (RTH) occurs in rare patients and its clinical presentation is considerably different than that seen in the usual hyperthyroid patient. Patients with this inherited condition produce inordinate levels of thyroid hormone because their negative feedback loop at the pituitary gland is metaphorically snipped. Concurrently, they have normal levels of thyroid-stimulating hormone.

Recurrent major depressive disorder episodes are linked to lower bone density in men, according to findings published in the Journal of Musculoskeletal and Neuronal Interactions.

An article published in Clinical Interventions in Aging outlined a large hospital's successful quality improvement interventions over 5 years to reduce medication errors in their large population of diabetic patients.

The FDA today approved two new diabetes drugs. The agency gave the nod to insulin degludec injection (Tresiba/Novo Nordisk) and insulin degludec/insulin aspart (Ryzodeg/Novo Nordisk)

Researchers looked at possible renal protective properties of an SGLT2 inhibitor.

Devoted soda drinkers began to lose their minds when an infographic outlining the harmful effects a single can of Coca-Cola has on the body in one hour began circulating the Internet. Now a new infographic has revealed what a Big Mac from McDonald's can do to the body in the same amount of time.