Hematology

A meta-analysis of four RCTs found Iron isomaltoside ferumoxytol is both effective and safe to treat iron deficiency anemia.

Voxelotor decreases oxygen extraction fraction and cerebral blood flow towards levels observed in healthy children.

No concerning patterns of long-term or increasing opioid use were observed within 3 years after first opioid prescription in opioid-naive children with SCD.

Hearing loss was more prevalent among children and adults with sickle cell disease and its traits compared to matched controls with normal hemoglobin.

Over the study period, pain screening procedures were integrated within routine clinical visits and providers’ workflow in sickle cell disease care.

Microalbuminuria and low body iron levels displayed a significant association with pediatric hearing loss independently.

The approval provides patients with the first-ever treatment option for severe frostbite to prevent the amputation of fingers or toes.

Mitapivat treatment was linked to long-term improvements in key markers of iron homeostasis and erythropoiesis in an analysis of the phase 3 ACTIVATE trial.

Non-breast milk-fed infants received more iron on average each day than breast-milk-fed infants, but experienced a higher rate of iron deficiency.

A new analysis cites relatively high hemoglobin levels as a protective factor for bone quality in patients with type 2 diabetes.

A trial comparing iron supplementation methods for postpartum maternal fatigue found similar fatigue reduction regardless of treatment type.

According to a new systematic review and meta-analysis, roxadustat's efficacy remains consistent across varying inflammation levels in patients with chronic kidney disease.

A Mendelian randomization study suggests a link between genetically lower iron levels and the risk of subsequently developing celiac disease.

Anemia showed an association with disability and suboptimal functional outcomes, but no association with neurological deficit or mortality, at 90 days post-stroke.

In this analysis, it is suggested that fetal growth trajectories require levels of oxygen promoted by the intake of maternal iron and hemoglobin.

Iron and vitamin D status during the second trimester predicted maternal depression symptoms during the third trimester.

In a new study, 7.9% of pregnant women without anemia during the first trimester developed anemia during the third trimester.

Test your knowledge with this clinician quiz! In this quiz, we test your knowledge of adjunctive tests in the diagnosis of iron deficiency anemia based on recommendations from the 2020 American Gastroenterological Association's clinical practice guidelines on gastrointestinal evaluation of iron deficiency anemia.

Compared to the usual care, patients with HFpEF in the active arms demonstrated less improvement in peakVO2 when they had iron deficiency and lower values of ferritin and transferrin saturation, according to a new study.

Lower levels of selenoprotein P were associated with reduced hemoglobin, greater transferrin receptor 1, and an increased prevalence of anemia in a cohort of hospitalized heart failure patients.

Observational data from the ARIC study reveals that lower plasma levels correlate with an increased risk of incident heart failure and diastolic dysfunction.

Patients on maintenance hemodialysis classified as having a high erythropoietin resistance index had a greater risk of all-cause mortality.

Analysis finds measures of iron deficiency, including ferritin, serum iron, and transferrin, were linked to an increased likelihood of depression in young adult males but not females.

Results of the PRECISION trial suggest use of iron-whey-protein microspheres could aid in improving adherence to oral iron therapy as well as staving off adverse GI events.

Moderate-to-severe anemia decreased the likelihood of a favorable outcome after mechanical thrombectomy compared with no anemia.

A study of more than 140 adults with diabetes is providing additional insight into the prevalence of anemia among these patients as well as its association with changes in glycemic control.

A systematic review combined with a pair of case studies suggest men who discontinue the front-line treatment for conditions like polycythaemia vera may improve their fertility.

A new study demonstrated hemoglobin levels significantly increased with ziltivekimab, showing the monoclonal antibody has the potential to serve as a new treatment method for anemia.

Keli Coleman, MD, discusses findings from her research about the role of pain scores and opioids in predicting hospitalization and return visits in children with sickle cell disease and uncomplicated pain crises.

Presented at ASH 2023, a new study demonstrated physical activity does not increase bleeding for patients with hemophilia A as patients with low physical activity still experienced frequent bleeding.