Osteoporosis

November's endocrine month in review features stories on the Build Back Better Act, a recent review from the IOF, data from Kidney Week 2021, and more.

The latest review from the International Osteoporosis Foundation is a 14-page document with more than 100 references outlining current data related to the pathophysiological links between vascular calcification and bone loss.

October's endocrine month in review features stories on the new ADA and EASD type 1 diabetes guidance, a phase 2 trial examining oral PTH tablets for osteoporosis, and a 3-part panel discussion focusing on diabetes management in 2021.

A propensity score-matched analysis comparing fracture risk associated with the initiation of SGLT2 inhibitors versus GLP-1RAs or DPP-4 inhibitors indicates use of SGLT2 inhibitors was not associated with an increase in risk of fractures in older patients with type 2 diabetes.

An analysis of more than 1.2 million patients who experienced a fracture from 1997-2017 provides insight into contemporary trends in fracture incidence rates based on presence of diabetes.

A phase 2 trial presented at ASBMR provides insight into the effects of oral PTH tablets on bone health among postmenopausal women with osteoporosis.

An analysis of patient data from a national registry in Denmark indicates use of alendronate was associated with reductions in odds of developing type 2 diabetes, with this reduction becoming greater with longer use of the osteoporosis medication.

The organization's first update since their 2010 position statement, the osteoporosis position statement reflects more than a decade of advances in knowledge related to diagnosis and management of osteoporosis.

A study from the University of South Australia assessing the impact of high-dose, short-term caffeine consumption suggests increased consumption could increase renal calcium clearance by 77% in healthy patients.

Using data from more than 2000 patients followed for 16 years, a Garvan Institute of Medical Research-led team found cognitive decline in older women could help predict bone loss and fracture risk among these patients.

An analysis of data from more than 1000 women in Australia suggests each incremental increase in abdominal aortic calcification was linked to a 3% increase in risk of fall-related hospitalizations.

An analysis of data from the Women's Health Initiative provides an overview of the risk of subsequent fracture seen among women with a history of traumatic versus nontraumatic fracture in postmenopausal women.

An analysis of data from more than 12,000 women in Asia is shedding new light on the prognostic value of BMD for predicting risk of atherosclerotic cardiovascular disease in aging women.

A new study is challenging the notion that certain types of fractures, such as lower arm or wrist fractures, do not signal increased risk of subsequent fractures among postmenopausal women.

A case-controlled study of 60 patients in the United Kingdom found presence neuropathy contributes to fracture risk in patients with type 1 diabetes but found other factors play a role in the increased risk among these patients.

Despite lower length of stays, costs of hip fracture surgeries have been on the rise in recent years and a new study suggests it could be linked to increased hospital charges rather than increased surgeon charges.

Switching from 60 mg to 30 mg denosumab every 6 months could be an option for patients who have completed long-term denosumab therapy, according to the results of a new study from McMaster University.

A Mass General-led analysis of claims data indicates less than 1-in-10 patients who suffer a hip fracture were prescribed an osteoporosis treatment in the next 6 months, while also providing data on trends in prescribing practices of newer agents.

Using data from the Osteoporotic Fractures in Men study, new research suggests incorporating AAC scores and PVFx could help predict older men at increased risk of fractures.

An analysis of data from the Veterans Health Administration is providing insight into the apparent increase in risk of fracture or osteoporosis among older adults with kidney or ureteral stones.

An analysis of more than 30k middle-aged adults from a prospective cohort study in Sweden is providing insight into the effects of exercise and other variables on fracture risk in these patients.

A survey of providers within the IOF and NOF provides insight into the effects of the COVID-19 pandemic on the diagnosis and treatment of osteoporosis across multiple regions throughout the world.

A phase 2 trial from investigators in the UK suggests use of denosumab, a human monoclonal antibody, could drastically reduce the rate of revision procedures after hip replacements.

An analysis of data from more than 1.2 million Korean women offers insight into how reproductive factors might impact fracture risk among postmenopausal women.

An analysis of 34k patients over more than a decade indicates living alone after a hip fracture was associated with a 37% increase in mortality risk among men and a 23% increase in risk among women.

This article features the top 5 stories in Endocrinology Network's coverage of osteoporosis management in 2020.

Results from a randomized trial suggest engaging in an exercise program following weight loss surgery could help protect against bone loss.

An analysis of more than 29k women from two medical centers in California is offering further insight into the effects of discontinuing bisphosphonate treatment in aging women.

A 600-patient trial suggests increased vitamin D supplementation was not associated with a decreased risk of falls but could increase risk of severe falls and fall-related injuries.

A new ACR study details the effects of romosozumab on bone mineral density gains when followed or preceded with antiresorptive medications such as alendronate or denosumab.