Schizophrenia

Aristada (aripiprazole lauroxil) extended-release injectable suspension for the treatment of schizophrenia features once-monthly and six-week dosing options.

Results from a pilot study suggest that a technique called "Mental Contrasting and Implementation Intentions" is a promising way to promote physical activity in patients with schizophrenia spectrum disorders.

Wrist–worn actigraphy might be an alternative to polysomnography (PSG) in measuring sleep efficiency and number of awakenings in certain patients with schizophrenia, according to a study in Neuropsychiatric Disease and Treatment.

Researchers have uncovered more evidence to support the hypothesis that lead contributes to schizophrenia onset.

The FDA approved cariprazine (Vraylar/Forest Labs) for treating schizophrenia and bipolar disorder in adults.

An article in Schizophrenia Bulletin makes a strong case for a scaling up of schizophrenia care that could yield breakthroughs in treatment for the condition and, ultimately, many other mental health disorders. Such a scaling up would involve breaking down significant barriers but could yield significant breakthroughs in treatment.

Investigators have shown that changes in toll-like receptor 4 (TLR4) mRNA expression level are significantly associated with major depressive disorder (MDD). The study, which appeared in Neuropsychiatric Disease and Treatment, is a follow-up to an earlier study by the same researchers that first established the connection between TLR4 and MDD.

Brain networks of schizophrenia patients are denser than healthy subjects, according to research in JAMA Psychiatry.

Safe, effective treatments for schizophrenia are well-established in the United States and worldwide, with several second-generation antipsychotics (SGAs) approved for use. But earlier schizophrenia studies have shown that several single nucleotide polymorphisms (SNPs) – the genetic variations that can underlie differences in susceptibility to disease – are overexpressed in Caucasian patients with schizophrenia but not in their Chinese counterparts, and vice versa.

Inflammation may play an important role in patients with schizophrenia, new research determined, which could lead to improved treatments.

The causes and pathogenesis of schizophrenia are still poorly understood, but new research aimed to find answers by looking at childhood milestones.

The "thinking problems" frequently experienced by patients with schizophrenia may be due to abnormal brain rhythms, according to research from UC San Francisco.

The US Food and Drug Administration (FDA) announced the approval of Rexulti (brexpiprazole) as a treatment option for adults with schizophrenia or major depressive disorder (MDD).

Immigrant populations tend to have nearly 2 times the prevalence of psychotic disorders compared to the general population of the host country.

Research from the University of California, San Diego School of Medicine and Veterans Affairs San Diego Healthcare System published online in the American Journal of Geriatric Psychiatry suggests that patients with post-traumatic stress disorder appear to be at risk for accelerated aging, or premature senescence.

The US Food and Drug Administration today approved 3-month paliperidone palmitate (Invega Trinza/Janssen) a longer-lasting version of Janssen's paliperidone palmitate product marketed as Invega Sustenna, a treatment that works for only 1 month per injection.

Researchers from Germany reported mouse models of schizophrenia experience both cognitive and emotional effects of schizophrenia.

Targeting oxytocin may be the answer to enhancing social function in patients with autism or schizophrenia, according to findings published by researchers from Emory University.

The Obama administration's former health policy guru Ezekiel "Zeke" Emanuel, MD, PhD, wants to bring back asylums. Deinstitutionalizing the mentally ill has been underway since the 1950s. But Emanuel, MD, and colleagues at University of Pennsylvania want the US to reopen these inpatient psychiatric facilities to provide long-term care for some patients. "Few high-quality accessible long-term care options are available for a significant segment of the approximately 10 million US residents with serious mental illness," he and colleagues write in a JAMA opinion piece.

An excess of long isoform nitric oxide synthase 1 adaptor protein, or NOS1AP, may be a cause of schizophrenia development, according to findings from Rutgers University.

Researchers have long known that the risk for schizophrenia is inherited. In new findings published online Sept 15 in The American Journal of Psychiatry, senior investigator C. Robert Cloninger, MD, PhD, of the Washington University School of Medicine in St. Louis, MO, said his team identified distinct gene clusters that contribute to 8 different classes of the disease.

Taking human pluripotent stem cells, reprogramming them to act like embryonic stem cells, and then getting those cells to create neurons has enabled researchers to create a "brain in a dish." In a dramatic demonstration of this technique's potential in neurological research, scientists recently took some of these neurons and reprogrammed them by using genetic material in skin cells taken from people with schizophrenia.

Although mental illness is widely perceived as a detriment to one's quality of life, recent findings claim schizophrenia does not necessarily forego happiness.

For schizophrenia patients, there is a connection between deficits in cognition and motivation related to their illness, according to new research.

Two recent studies have identified gene variants and mutations that significantly increased the likelihood of schizophrenia, alcoholism, and bipolar disorder development.

Providing additional insight into mental illnesses such as schizophrenia and bipolar disorder, recent research has found neurological operations at rest are similar to those seen during active tasks.

Patients who experience a head injury have an increased risk of receiving a subsequent diagnosis for a psychiatric disorder.

Schizophrenia is typically caused by damage to several genes, rather than a single genetic mutation.

New research has uncovered increased rates of dementia, chronic obstructive pulmonary disease, and several other disorders in older adults with schizophrenia.

Taken as monotherapy or together with antidepressants or other mood stabilizers, Invega Sustenna (paliperidone palmitate) reduces relapse in schizoaffective patients.