Personalized, Aggressive Care for Pulmonary Arterial Hypertension
The addition of a couple of new drug classes at the turn of the century have given clinicians the greenlight to stack therapies at initial treatment.
How Type 2 Cytokines Burden Severe Asthma
There’s a challenge to achieve control in some asthma patients since the disease is heterogenous—both allergic and non-allergic triggers can initiate Type 2 inflammatory pathways that can drive pathology.
Joshua Denson, MD, MS: Comorbidities Associated with Asthma
Joshua Denson, MD, MS, discusses the comorbidities associated with asthma.
Adjusting Endothelin Receptor Antagonists for Real-World PAH Patients
Now that real-world data registries are being compiled, the constriction-limiting drug class is now going through personalizations including new titration strategies.
Antonio R. Anzueto, MD: Biomarkers in COPD
Antonion R. Anzueto, MD, covers the latest research regarding biomarkers in COPD, outlining possible avenues of investigation and addressing regional causes of the disease.
ICU Care Improved with Conflict Management Education
Conflict management education intervention, which includes elements of compromise and awareness, helps improve ICU care.
Monica Kraft, MD: Dupilumab's Two-Fold Targeting
What makes the monoclonal antibody so enticing to the asthma community?
Two Dupilumab Doses Improve Adolescent Asthma Lung Function
A 200 mg dose of the monoclonal antibody was also shown to significantly reduce ashtma exacerbations over 1 year versus placebo.
Hospital Readmissions Driven by Length of Stay, Smoking, Comorbidities
A retrospective review of rural region's hospitals found that even the discharge time of day could be associated with a greater chance of readmission.
Non-Pharmacological & Pharmacological Therapies in Tobacco Cessation
Investigators from Brooke Army Medical Center discuss pharmacological and non-pharmacological treatment strategies for tobacco cessation.
Hospitalized ILD Patients Fare Much Worse from Gram-Negative Bacteria
Gram-negative bacteria excluding Pseudomonas Aeruginosa has been associated with greater rates of patient mortality, vasopressor administration, and ICU admission.
Investigators Reconsider ASV Device Risks for CSA-HFrEF Patients
Investigators found that treating for CSA in the patient population significantly decreases mortality risk—despite previous clinical warnings.
Secondhand Factors in Asthma Not Significant in Overall Disease Improvement
Secondhand factors in asthma, such as environmental exposures like pets and secondhand smoke, are not significant in overall disease improvement.
Gender Differences Discovered in Emerging OSA Phenotype
Investigators have shared new disparities of characteristics in men and women with differing severities of respiratory arousal threshold.
Women Lung Donors Less Likely to Receive Lung Protective Tidal Volumes
Women are less likely to be administered lung protective tidal volumes (TVs) when being considered as a lung donor.
Triple Therapy Improves COPD Exacerbations Regardless of Reversibility Status
More IMPACT trial results shows Trelegy Ellipta has benefits for both reversible and nonreversible COPD patients in exacerbations and lung function versus dual therapy.
Female CHEST Fellow Applicants on the Rise
Data show that while women are underrepresented as fellows of the American College of Chest Physicians, the volume of women applying is increasing.
Therapy Disruption by Medicare Coverage Could Harm Asthma Control
A new study found that Medicare Part D formulary shifts sometimes result in asthma patients forgoing controller therapy altogether.
GSK Submits NUCALA for COPD Indications
The biologic agent has shown efficacy in reducing asthma exacerbations and improving patient quality of life.
Esbriet for IPF: Reconsidering Its Role
Gordon L. Yung, MD, FCCP, explains the right patient perspective of the antifibrotic therapy.
Excessive Sleep Therapy For OSA Marks Strong Phase 3 Results
Almost 500 patients were split into 4 dosing groups for JZP-110.
Changing Inhalers Does Not Cause Worse Technique
Researchers studied recently-referred COPD patients and what attributes put them at risk for poor inhaler device technique.
Lisa Moores, MD: Challenges in Diagnosing VTE During Pregnancy
Many of the symptoms of VTE are normal during pregnancy, and it's difficult to find a suitable population to test out new diagnostic and therapeutic methods.
Vipin Malik, MD: What To Do During In-Flight Medical Emergencies
There's a medical emergency in one in every 604 flights. Here's what doctors need to know so they can handle them appropriately.
Breo Ellipta Proves Non-inferior to Asthma Therapies, Affordable for COPD with CV Risks
Two consecutive CHEST studies showed combination therapy's expanding portfolio.
Barbara Phillips, MD: How Doctors Can Prevent Commercial Vehicle Crashes
Commercial drivers are very unlikely to admit to symptoms that might result in loss of working time and money. That's where their primary care physicians come in.
Barry Fields, MD: Biggest Challenges in Sleep Telemedicine
Telemedicine is extraordinarily promising for patients and practitioners, but there are lingering challenges that are keeping it from reaching its full potential.
Craig Lilly, MD: How Tele-ICUs are Revolutionizing Intensive Care
Telemedicine is more than just a trend in medicine – it's one of the most potent tools available to health systems and patients alike.
Dupilumab Adds to Its Uncontrolled Asthma Portfolio
Regeneron and Sanofi released more positive phase 3 trial results, a day following phase 2b results were shared at CHEST.
Darcy Marciniuk, MD: New Methods for the Treatment of COPD
Clinicians now have pharmacologic and nonpharmacologic treatments that can be very effective for the common condition.