Endothelin Pathway

Author(s):

Manesh R. Patel, MD,Payal Kohli, MD, FACC

Key Takeaways

Difficult-to-treat hypertension involves uncontrolled blood pressure despite using three or more antihypertensive medications, including a diuretic.
It is distinct from resistant hypertension, which is more common and may not include a diuretic in treatment.
This condition affects a smaller subset of patients with high blood pressure and requires a comprehensive management approach.
Lifestyle modifications and evaluation for secondary causes are crucial for optimal management of difficult-to-treat hypertension.

Panelists discuss how the endothelin pathway critically regulates blood pressure and vascular health through the interplay between vasodilators and vasoconstrictors such as endothelin-1, representing a key mechanism in hypertension pathophysiology.

EP: 1.Unmet Needs in HTN: Patient Adherence, Comorbid Conditions, and Prevalence

EP: 2.Current Limitations With Traditional Antihypertensive Drugs

EP: 3.Drug Classes Available to Treat Patients With High Blood Pressure

EP: 4.Difficult-to-Treat Hypertension Treatment Strategies

EP: 5.Current Therapeutic Guidelines for Managing Resistant Hypertension

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EP: 6.Endothelin Pathway

Video content above is prompted by the following:

There are numerous factors that contribute to the pathophysiology of hypertension. One is the endothelin pathway, which plays a crucial role in regulating vascular tone, blood pressure, and vascular remodeling via vasodilators (eg, nitric oxide) and vasoconstrictors (eg, endothelin-1).