Arash Mostaghimi, MD, MPH

Panelists discuss the efficacy and safety data for ritlecitinib and deuruxolitinib in treating alopecia areata, highlighting that ritlecitinib achieved SALT scores of ≤20 in 23% of patients at week 24 compared to 1.6% in the placebo group, while deuruxolitinib showed SALT scores of ≤20 in 42.5% (8mg BID ) and 56.8% (12mg BID) of patients, with treatment-emergent adverse events primarily being mild to moderate, including upper respiratory tract infections and headaches for ritlecitinib, and headache and acne for deuruxolitinib.

Panelists discuss their clinical experiences with Janus kinase (JAK) inhibitors for treating alopecia, noting observed differences in outcomes and tolerability among various systemic JAK inhibitors, while highlighting the advantages of these therapies over traditional local and systemic treatment options.

Panelists discuss how they determine disease severity in patients with alopecia areata, highlighting the tools used in clinical practice, such as the AA scale 2022 and the ASAMI study 2024.

Panelists discuss whether there are specific patient characteristics that are typically associated with the presentation of alopecia areata.

Panelists discuss how early diagnosis and the utilization of systemic Janus kinase inhibitors are crucial in the effective management of alopecia areata, highlighting the impact of disease severity and patient experiences on treatment strategies.