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JAK Inhibition in the Treatment of Alopecia Areata

Key Takeaways

  • Baricitinib and deuruxolitinib inhibit JAK1/2, while ritlecitinib targets JAK3 and TEC, reflecting different mechanisms of action in alopecia treatment.
  • Selective inhibition focuses on specific JAK pathways, potentially minimizing off-target effects and improving safety profiles.
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Video content above is prompted by the following:

Three JAK inhibitors are FDA-approved for the treatment of alopecia: baricitinib and deuruxolitinib (JAK1/2 inhibitors), and ritlecitinib (selective JAK3 and TEC inhibitor). Can you talk about the differences in mechanisms of action and how they might influence treatment efficacy for alopecia?

How does selective inhibition differ from pan-inhibition?

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