Rodrigo Barros

Researchers are investigating whether microbial therapy can be an effective treatment for several skin and allergic conditions.

The gut microbiota modulates immune development and is an important component of neuroendocrine system. These interactions interfere with neuroendocrine development and, consequently, the patient's immune function.

Dietary amino acids are converted by the luminal microbiome in the gut to a bioactive compound, histamine, which binds to H2R and suppresses MAP kinase signaling and proinflammatory cytokines.

SLIT-tablets have a safety profile suitable for home treatment, as long as the first tablet intake is done under medical supervision. Long-term outcomes seem to differ between grass pollen SLIT-tablet products, and further studies are required.

Comparing safety and efficacy between sublingual immunotherapy and subcutaneous immunotherapy.

Clinicians have several options when it comes to treating their allergic patients with subcutaneous (SCIT) or sublingual (SLIT) immunotherapy.

Evidence shows that patients with chronic urticaria have autoimmunity, reduced basophil number and function, and precedent or concurrent infections.

Researchers have been investigating potential mechanisms involved in the generation of urticarial lesions, the role of IgE-targeting in allergic diseases, and the clinical characteristics of chronic spontaneous urticaria.

Clinicians have several guidelines, algorithms, and other tools at their disposal that can assist them in the differential diagnosis and management of chronic urticaria.

The skin microbiome may have beneficial influence on the skin through three mechanisms: direct inhibition of pathogen growth, improvement of the host's immune system, and education and priming of the adaptive immune system

The incidence of allergic asthma and other airway diseases in childhood has increased in industrialized societies, and it is known that environmental exposures play a role in their development.

Studies show that children exposed to a more diverse microbial environment in early life may have lower risk for allergy, asthma, and other disorders.