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Alogliptin: The newest agent to fight the diabetes pandemicAccording to the American Diabetes Association (ADA), 23.6 million children and adults have diabetes (8% of the US population) and another 5.7 million cases remain undiagnosed. Epidemiologists predict that these statistics will double by 2030, further taxing the healthcare system. Medical expenditures are approximately 2.3 times higher for diabetic versus nondiabetic patients, and the annual cost of diabetes is estimated to be $116 billion.
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Going South: The Toll of Smoking on Kentucky & West VirginiaTobacco farm region physicians face the challenges of culture, law, and education in improving cessation.
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Shifting the Diagnostic Paradigm: A Novel Diagnostic Approach for Evaluating Suspected Coronary Artery DiseaseIt's time to redirect the initial evaluation of low- to intermediate-risk patients presenting with symptoms suggestive of CAD back to the primary care and internal medicine setting.
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The Role of Stigma in Irritable Bowel SyndromeThe stigma attached to chronic diseases such as IBS has been shown to negatively affect patients' self-image and sense of worth, leading to worse outcomes. Being aware of this and working to counteract the psychological effects of stigma can improve the patient-physician relationship and lead to better outcomes.
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Clinical Trial Disparities: A Case for DiversityThe challenge of eliminating disparities in clinical trials is being addressed by the Eliminating Disparities in Clinical Trials (EDICT) project, which recognizes that broadening diversity in clinical trials will result in improved effectiveness and safety of future medicines, improved trial quality, and reduced discrepancies in health equity.
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Prevention of postoperative atrial fibrillationAtrial fibrillation (AF) is common after cardiac surgery, occurring in 11% to 40% of patients after coronary artery bypass grafting (CABG)1-8 and in more than 50% of patients after valvular heart surgery.
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Latest News and Updates on C. Difficile Infection Management and TreatmentWe present a round-up of recent news, trial results, and other developments for infectious disease experts and other physicians who treat patients with C. difficile infection.
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Using PCSK9 Inhibitors to Reduce Major Cardiovascular OutcomesResearchers have been investigating whether PCSK9 inhibitors can protect other patients at high risk for a cardiovascular event.
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A Stimulating TopicThanks to new technologies, children are receiving state-of-the-art neurological care at Cook Children's Medical Center.
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The cost of failureWhen considering the article by Goldberg and colleagues, it seems reasonable to request a change in the title to "Survival after the diagnosis of  heart failure."
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Pediatric MDS Update with Dr. Inga Hofmann ZhangDr. Inga Hofman Zhang from the University of Wisconsin School of Medicine provides an update on treating MDS in children.
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Migraine Prevention Moves Into Focus With New Clinical TrialsStudies offer hope that CGRP antibodies will lead to better treatment for disabling headaches.
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How do cardiac and noncardiac conditions affect survival after ICD implantation?The benefits of implantable cardioverter-defibrillators (ICDs) have been shown in randomized clinical trials. The factors that affect the risk–benefit ratio in a community setting, however, have not been evaluated.
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Understanding, Valuing The Medical Journey to Weight LossThe paradigm of obesity is complex and requires a multi-disciplinary approach, but it is one of the most gratifying experiences for both the physicians and patient when they see the results of weight loss.
