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Achieving Meaningful Use: A Health System PerspectiveThe experience of Partners HealthCare offers some unique insights into the process of electronic medical record adoption across a large, diverse health system.
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High clopidogrel maintenance dosage in patients with diabetes mellitus and coronary artery diseasePatients with type 2 diabetes mellitus have decreased platelet inhibition and decreased responsiveness to standard doses of clopidogrel compared with patients without diabetes. In this pilot study, we showed that increasing the maintenance dose of clopidogrel to 150 mg leads to enhanced platelet inhibition compared with the standard dose of 75 mg in patients with type 2 diabetes with suboptimal responsiveness. The clinical implications of these findings are unknown, however, and need to be evaluated in large-scale clinical trials.
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Tech Sectors: Biotechnology: The Treatment of Palmar-plantar ErythrodysesthesiaA potential new candidate uses uracil to combat this cancer treatment side effect.
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Antiviral Treatment vs. Herpes Zoster Vaccines for Postherpetic NeuralgiaThis review and meta-analysis assessed whether antiviral treatment given during the acute herpes zoster rash is effective at preventing postherpetic neuralgia in patients with a first-time case of shingles.
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The safety of long-term low cholesterol levelsIn their study, Strandberg and Strandberg (page 13) found that during a 39-year follow-up of initially healthy men, aged 30 to 45 years (mean, 38 years), low serum cholesterol levels predicted better survival, better physical function, and better quality of life in old age, without adversely affecting mental functioning.
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Evaluating a Young Patient with Joint Pain and Stiffness Part 2You see a 29-year-old female insurance saleswoman with a 6-week history of joint pains and swelling affecting both hands and wrists, both feet and her left knee. Her symptoms are worse when she first gets up in the morning and it takes a few hours before her joints seem to loosen up.
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Iatrogenic dilated cardiomyopathy and spectrum of current treatment modalitiesOur increasing ability to intervene in high-risk patients—with lower risks and greater chances for successful outcomes—is felt across the broad spectrum of cardiovascular disease. This is particularly evident in patients with dilated cardiomyopathy (DCM).
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Back to the Future: Why Are More Women Having Bilateral Mastectomy for Unilateral Breast Cancer?Since 2003, the rate of women choosing breast-conserving surgery for the management of early-stage breast cancer has declined, with an accompanying recidivism to mastectomy. Edibaldo Silva, MD, PhD, examines the reasons for the treatment regression.
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The Industry Insider: April 2007Companies in the news: 1) AVAX and CTCA Collaborating for Cancer Therapies 2) Full Speed Ahead for GPC Biotech's Satraplatin 3) Bristol-Myers Squibb Company / Adnexus Therapeutics: Collaboration for New Oncology Compounds 4) Graffinity and Amgen in Drug Discovery Agreement 5) Roche Suspends Enrollment in CERA Phase II Oncology Trial
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Multiple Genetic Variants Likely Underlie Early Onset Drusen MaculopathyWhole genome sequencing suggests both common and rare variants contribute to early onset drusen maculopathy.
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ASH Interview SeriesThe December issue of Oncology & Biotech News featured highlights from the 51st American Society of Hematology (ASH) Annual Meeting and Exposition. We wrap up our ASH coverage this month with interviews on multiple myeloma with Brian G.M. Durie, MD, medical director and co-founder of the International Myeloma Foundation; chronic lymphocytic leukemia (CLL) with Robert J. Kreitman, MD, from the National Cancer Institute; and chronic myeloid leukemia (CML) with Francis J. Giles, MD, Cancer Therapy and Research Center at The University of Texas Health Science Center in San Antonio.
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Never too old for statinsElderly patients with a history of an acute coronary syndrome (ACS) are at higher risk for subsequent cardiovascular events than younger patients.
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Can Red Meat be Part of a Healthy Diet?Over the past four decades, red meat has gotten a bad rap. Consumption of beef, pork, and lamb has been linked with poor cholesterol scores and increased risk of breast, colon, and rectal cancers as well as diabetes and a host of other chronic diseases. The conventional wisdom has, however, lumped all red meats into a single group and arrived at a blanket judgment that eating any red meat is equally harmful.
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Contemporary cardiac imaging in hypertrophic obstructive cardiomyopathyFeatures of hypertrophic obstructive cardiomyopathy (HOCM) include obstruction at the left ventricular outflow tract (caused by a markedly thickened proximal interventricular septum) and systolic anterior motion of the mitral valve. The case discussed here illustrates several classic features of this disease including clinical presentation, diagnostic workup, and noninvasive and invasive management.
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A Classic Case of Mitral Valve EndocarditisA young woman presented with fevers, chills and a holosystolic murmur that radiated to her axilla, and became louder with handgrip maneuvers.
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Can reduction in electrocardiographic left ventricular hypertrophy be helpful in preventing clinical heart failure?As clinical cardiologists, we face an ever-changing landscape with regard to the management and care of hypertensive patients.
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Obesity-related hypertensionTo evaluate the interactions between the weight loss drug, sibutramine, and different antihypertensive treatments, we randomly assigned 171 subjects taking 3 antihypertensive treatment regimens to receive sibutramine or placebo. Our study showed for the first time that combination therapy with an angiotensin-converting enzyme inhibitor and a calcium channel blocker is more advantageous than a ß blocker/diuretic-based-regimen with regard to supporting the weight-reducing actions and metabolic changes induced by sibutramine.
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Why Online Social Networking Should Change What We Know about Health CareRather than being a force for depersonalizing medicine and driving a wedge between patients and physicians, it turns out that information technology and social media offer new opportunities for deeper communication and interaction.
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Ten Questions to Ask Yourself before Choosing a New BankUse the negative financial climate to your advantage when choosing a new banking partner. These ten questions will help you determine whether the banks on your short list can handle your needs.
