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Traditional risk factors across short-, intermediate-, and long-term follow-up in men and womenWe found sex differences in the pattern of relative strength when riskfactor associations with death from cardiovascular disease (CVD) were evaluated across different periods of follow-up. In women, an increased risk in CVD-related death was associated with diabetes mellitus and smoking; this risk was most prominent in the early follow-up period. Our finding illustrates that clinicians should employ more intense preventive measures in women who are smokers or have diabetes.
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Is There a Future for PARP Inhibitors in Ovarian Cancer?PARP inhibitors are promising agents, particularly for cancers associated with BRCA gene mutations.
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The vegetarian paradox: Low HDL cholesterol levels and low cardiovascular riskEver since the observation in the 1950s that high-density lipoprotein (HDL) cholesterol was inversely correlated with coronary artery disease, there have been confounding data that have not been reconciled.
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Antihypertensive Combination Drugs: Effectiveness, Adherence, and Pleiotropic EffectsThe decreasing age of onset of hypertension in the general population paired with increasing life expectancy has resulted in an increased incidence of this disorder, which will likely culminate in higher rates of morbidity and mortality in the future.
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Red Blood Cell Transfusion in Patients Undergoing PCIThe role of blood transfusions in patients undergoing percutaneous coronary intervention remains controversial.
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Private Practice Is Fighting for SurvivalA variety of forces are threatening the sustainability of private practice in today's medical environment. In the face of these and other trends, can physicians survive in private practice?
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Statistics - Using the Truth to MisleadDr. Pullen examines the importance of statistics in medicine, how the meaning of them can often be hard to interpret, and the need, perhaps, for more statistics courses in medical school.
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COVID-19 Webinar: Debating the Road Back to SchoolJoin us tomorrow for an informative discussion on CDC guidance and insights from medical experts on navigating a way back to in-school learning.
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Managing Opioid-induced ConstipationThe key to managing opioid-induced constipation is early recognition of the problem.
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What to Tell the Kids about Caitlyn Jenner: the Transgender TalkBruce Jenner's transformation into Caitlyn Jenner is global news. It's a good time to discuss gender issues--but how?
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Medication Overuse Headache: When the Cure is the Cause of the PainAlso known as rebound headache, medication overuse headache is a fairly common condition that can be missed by non-specialists who are unfamiliar with its presentation and clinical signs. This article reviews the causes and types of medication overuse headache and discusses the current thinking on treatment.
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Providing Pediatric Cancer Patients With Tools to Boost Resiliency During TreatmentE. Anders Kolb, MD, Director of Nemours Center for Cancer and Blood Disorders at Nemours/Alfred I. duPont Hospital for Children, explains the importance of teaching resiliency as an educational tool and addressing the psychosocial burdens placed on patients in pediatric oncology.
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Unusual appearance of a left ventricular mural thrombusPostpartum cardiomyopathy is a serious disorder that can present from the third trimester to up to 5 months after pregnancy. Although spontaneous resolution of cardiac function occurs in more than half of patients (over a period of 6-12 months), the balance is left with persistent cardiac dysfunction. Cardiac dysfunction results in signs and symptoms of left heart failure, formation of apical or left ventricular thrombi, and arrhythmias and requires management similar to that in patients with nonischemic dilated cardiomyopathy.
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Different Language Versions of Urticaria Control Test Lost Nothing in TranslationA novel cross-cultural adaptation of the Urticaria Control Test (UCT) for clinical applications in Thailand proved every bit as effective as its German predecessor.
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Sewage screening, It's a Public Health Good ThingOther parts of the world scrutinize public sewage to look for disease markers. But not the US. In Israel, public health authorities recently found some lethal pathogens. With concern about Ebola so high, isn't this a good time to think about using this simple, non-invasive way to monitor threats from infectious organisms?
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The Match Trial: Disappointments and surprisesThe negative results of the Management of Atherothrombosis with Clopidogrel in High-risk patients (MATCH) Trial1 are disappointing and surprising, but perhaps this can be said about the conduct of the trial itself.
