Endocrinology

Researchers have identified a previously unrecognized mechanism for SGLT2 inhibitors in the regulation of glucagon and gluconeogenic gene expression.

Patients with type 1 diabetes who had more depressive symptoms measured at baseline and over time appear to be at an increased risk of mortality, even after allowing for likely mediators.

Designated "meaningful users" of electronic health record systems do not deliver improved care for common chronic diseases.

Although clinicians are increasingly forced to face the 3-headed monster of comorbid diabetes, sleep disturbance, and pain, the healthcare community is only beginning to understand how the conditions overlap.

By blocking a key pain receptor in mice models, a team of researchers has discovered a potential new method for treating obesity and diabetes.

Patients with type 2 diabetes and inadequate glycemic control treated with dapagliflozin plus metformin and sulfonylurea experienced sustained improvements in HbA1c, fasting plasma glucose, weight loss, and systolic blood pressure over 52 weeks.

Patients between the ages of 55 and 80 with type 2 diabetes treated with canagliflozin for more than 100 weeks experienced significant reductions in HbA1C, fasting plasma glucose, bodyweight, and systolic blood pressure.

Study results show long-term treatment with empagliflozin was well tolerated and associated with reductions in HbA1c, bodyweight, and systolic blood pressure compared with placebo and sitagliptin.

Contrary to popular belief, patients who are prescribed antidepressants experience only minimal weight gain within 12 months of treatment.

To decrease the rates of obesity and type 2 diabetes mellitus (T2DM), a recent study has recommended a ban on sugar-sweetened drinks among food stamp recipients and endorsed an incentive program to encourage healthier eating habits.

Study results presented at ADA 2014 show combination treatment with metformin plus linagliptin delivered consistent HbA1c reductions across different subgroups of patients newly diagnosed with type 2 diabetes, with decreased risk of hypoglycemia.

It is essential to educate patients on the importance of working with board-certified plastic surgeons and ensuring their cosmetic procedures performed at accredited locations.

In response to the growing prevalence of gestational diabetes mellitus and its associated morbidities, much attention has been paid to the use of appropriate screening methodologies for the metabolic disorder.

Study results show that an alternative to currently-marketed injectable agents retains the efficacy of GLP-1 mimetics, while reducing gastrointestinal adverse events and providing the convenience of oral dosing.

Results from the largest population-based, case-control study on the link between incretin therapy and pancreatitis conducted to date indicate that treatment with this class of medications does not confer increased risk of developing pancreatitis.

Combination treatment with insulin degludec and liraglutide was associated with long-term reductions in HbA1c, reduced hypoglycemia risk, and fewer gastrointestinal side effects compared to treatment with the individual medications alone in patients with diabetes.

Patients treated with a new, more concentrated insulin glargine formulation experienced similar glycemic control with fewer nocturnal and daytime hypoglycemic events compared with patients treated with the current formulation of the product.

Study results presented at ADA 2014 show Eli Lilly's investigational long-acting basal insulin analog to have similar clinical efficacy in reducing HbA1c levels as a currently approved injectable insulin glargine product, with a comparable side effect profile.

Among HIV-positive injection drug users, food insecurity is associated with mortality despite the use of antiretroviral therapy.

While a variety of surgical procedures can treat menorrhagia in premenopausal women, a recent study added a non-surgical alternative to the mix.

Just weeks after Australian researchers published data suggesting that testosterone replacement therapy does not ameliorate type 2 diabetes among hypogonadal men, a team of American researchers has unveiled a second study that suggests just the opposite.

Perhaps, a very simple change in beverage choice could reduce the stroke burden in the United States.

After examining the failures of parenteral nutrition, researchers have found starvation may promote cell recycling by inducing detoxification and autophagy - a survival mechanism that recycles intracellular nutrients like toxic protein aggregates and damaged organelles.

The American Academy of Pediatrics designed the 2014 Recommendations for Pediatrics Preventive Health Care to guide well-child care, but there is controversy over some of the changes.

The newer non-ergoline-derived dopaminergic agents appear to cause only minimal endocrine effects when used to treat idiopathic Parkinson's disease.

Findings from a pair of ongoing studies into the effects of testosterone replacement therapy indicate unexpected significant improvements for obese patients.

Prebiotics and probiotics have been discussed frequently in the media for supposedly improving overall health, especially diseases related to the gut. However, the evidence on the efficacy and use of these dietary supplements is rather complicated.

After studying an Amish population, researchers at the University of Maryland Medical Center have discovered a mutation in a fat-storage gene that increases a patient's risk for type 2 diabetes.

AstraZeneca's Epanova (omega-3-carboxylic acids) was approved by the FDA for the treatment of adults with severe hypertriglyceridemia; two new studies support the concept that there can be too much of a good thing when it comes to exercise; and the FDA has issued a new statement recommending against the use of aspirin to prevent a first heart attack or stroke in people with no history of cardiovascular disease.

It is primarily the responsibility of parents, teachers, and health care professionals to be role models for the younger generation with respect to healthy eating and physical activity.