Geriatrics

Zinc is the second most abundant trace element in the human body after iron, and is present in high concentration in the human eye.

There is a found significant unmet need to develop treatments that limit or protect against scar formation, GA development, retinal thinning, fluid increase, and lesions, as an accompaniment to anti-VEGF therapy.

The findings lend to investigators believe that earlier endpoints for AMD diagnosis are needed.

In animal models, not only did the drug help protect apelin function-deficient models from laser-induced choroidal neovascularization, but it did it through unique mechanisms that were independent of VEGF function.

The Novartis humanized single-chain antibody fragment previously showed improved best corrected visual acuity in patients with nAMD versus aflibercept.

Computers can do as well as clinicians in diagnosing age-related macular degeneration, say investigators who have developed tools based on artificial intelligence to detect the disorder.

Investigators reported an overall mean estimation error ranging from 3.47% to 5.29% in five-year outcomes for patients with AMD.

The acceptance comes less than a month since the FDA had approved the anti-VEGF therapy for the treatment of wet AMD. Its mechanism of action allows it to block new blood vessel growth and the passing of fluids through blood vessels in the eye.

A recent study found the costs of medical, laser, and surgical interventions were 2.5% or more of the median annual household income for many patients worldwide.

Among patients who were lost to follow-up over a year, just 7.4% attended a follow-up visit after the observed 12 months. In the total loss to follow-up patient population, they reported a mean 7.8 injection treatments and 8.5 clinic visits. In patients not lost, they reported a mean 14.3 injections and 17.1 visits.

The COMPASS-XT five-year analysis reported that patients treated with the micro-stent experienced statistically significant loss of endothelial cells compared to the patients treated with lone cataract surgery.

A modified 12-week dosing schedule is now available for physicians administering the vascular endothelial growth factor (VEGF) inhibitor to patients with wet age-related macular degeneration.

The results of a new study point to age-related macular degeneration, diabetic retinopathy, and glaucoma as potential early warning signs that an individual is at risk for developing Alzheimer disease or dementia.

In an effort to reprogram retina cell regeneration, investigators activated dormant stem cells then aided other stem cells in developing into rod photoreceptor cells—the most abundant cell type in the retina which first aid the retina in sensing light.

A post-hoc analysis of data from the TREX-AMD trial has determined that eyes with neovascular age-related macular degeneration and treated with ranibizumab, develop more macular atrophy lesions within baseline choroidal neovascularization regions than outside those regions.

Study results demonstrate that low-dose proton beam irradiation may enhance and extend the effects of anti-vascular endothelial growth factor (anti-VEGF) therapy for age-related macular degeneration.

The REGENXBIO drug's promising phase 1 results has led to the addition of a fourth patient dosing cohort and a phase 2 trial initiation.

Recent research suggests that reticular pseudodrusen may be associated with the progression of early AMD to GA. Although an association has been theorized between pseudodrusen and AMD, researchers remain unclear on the pathogenesis of reticular pseudodrusen.

People who ate at least 1 serving of oranges every day had more than a 60% reduced risk of developing late-stage macular degeneration in that time period.

The DR market is expected to accrue a sum of $2,490 million by 2022, growing at a compound annual growth rate of 14.4% from 2014-2022.

Risk of scar development increased from three-fold at 2 years to 4.5-fold at 5 years, possibly as a result of treated quiescent classic lesions that relapsed over time.

How come treat-and-extend may not be the most ideal therapy regimen for retina disease, and how biologics change physicians' perspective on dosing.

Are anti-VEGF and PRP therapies the best-case scenario for patients with AMD, or will gene therapies reach the market in the near future?

How the three-year results of a gene therapy for inherited retinal disease may redefine its potential in ophthalmology.

A three-year update of VN for patients with biallelic RPE65 mutation-associated inherited retinal disease improved on the common standard-of-care for retina disease.

Results from the PACORES group clinical trial debunked previously-held beliefs that IVB is unsafe for patients with proliferative diabetic retinopathy undergoing the procedure.

Why substantial evidence is lacking to indicate either therapy method's preference for the treatment of neovascularization.

The cheaper intravitreal anti-VEGF options improved visual acuity in the eyes of patients with 5 different retinal conditions.

How improvements to patient education, drug costs, and biosimilar therapy availability could keep patients with retina disease away from risky procedures.

Telemedicine screenings provided by a primary care office in an urbanized setting over 2 years showed patients had an 81.9% compliance capture rate—a significant improvement from previous studies in the same field.