Internal Medicine

The FDA has granted priority review for a New Drug Application submitted by AbbVie Inc. for its all-oral, interferon-free therapy for patients with chronic genotype 1 hepatitis C virus infection.

By blocking a key pain receptor in mice models, a team of researchers has discovered a potential new method for treating obesity and diabetes.

Resting-state functional MRI, a new MRI approach, detects early stage Parkinson's disease with 85% accuracy, according to a new study.

Older men who take statins reported lower levels of physical activity than nonusers, according to a new study.

Patients with type 2 diabetes and inadequate glycemic control treated with dapagliflozin plus metformin and sulfonylurea experienced sustained improvements in HbA1c, fasting plasma glucose, weight loss, and systolic blood pressure over 52 weeks.

Patients between the ages of 55 and 80 with type 2 diabetes treated with canagliflozin for more than 100 weeks experienced significant reductions in HbA1C, fasting plasma glucose, bodyweight, and systolic blood pressure.

Study results show long-term treatment with empagliflozin was well tolerated and associated with reductions in HbA1c, bodyweight, and systolic blood pressure compared with placebo and sitagliptin.

Contrary to popular belief, patients who are prescribed antidepressants experience only minimal weight gain within 12 months of treatment.

To decrease the rates of obesity and type 2 diabetes mellitus (T2DM), a recent study has recommended a ban on sugar-sweetened drinks among food stamp recipients and endorsed an incentive program to encourage healthier eating habits.

After several once-promising drugs failed to treat Alzheimer's disease in clinical trials, researchers at Penn State University claim to have found a new target for future treatments.

Study results presented at ADA 2014 show combination treatment with metformin plus linagliptin delivered consistent HbA1c reductions across different subgroups of patients newly diagnosed with type 2 diabetes, with decreased risk of hypoglycemia.

Cardiology guideline recommendations that are based on multiple randomized studies have the most durability over time, researchers from the University of Pennsylvania have found.

Study results show that an alternative to currently-marketed injectable agents retains the efficacy of GLP-1 mimetics, while reducing gastrointestinal adverse events and providing the convenience of oral dosing.

Results from the largest population-based, case-control study on the link between incretin therapy and pancreatitis conducted to date indicate that treatment with this class of medications does not confer increased risk of developing pancreatitis.

Combination treatment with insulin degludec and liraglutide was associated with long-term reductions in HbA1c, reduced hypoglycemia risk, and fewer gastrointestinal side effects compared to treatment with the individual medications alone in patients with diabetes.

Patients treated with a new, more concentrated insulin glargine formulation experienced similar glycemic control with fewer nocturnal and daytime hypoglycemic events compared with patients treated with the current formulation of the product.

Study results presented at ADA 2014 show Eli Lilly's investigational long-acting basal insulin analog to have similar clinical efficacy in reducing HbA1c levels as a currently approved injectable insulin glargine product, with a comparable side effect profile.

Genetics contribute to depressive symptoms, which are linked to sleep duration, according to a study published in Sleep.

The US Food and Drug Administration partially lifted a clinical hold on a hepatitis C drug under development by Achillion Pharmaceuticals, clearing the way for a restart of the company's clinical trials of sovaprevir.

Opexa Therapeutics is initiating a phase IIb trial of a novel therapy that targets T-cells in patients with secondary progressive multiple sclerosis.

Pregnant women with hypertension who also snored were found to be at high risk for obstructive sleep apnea, spurring the need for obstetric healthcare providers to consider sleep evaluation in hypertensive pregnancies.

Comparatively few patients treated for anaphylaxis in the emergency department are prescribed adrenaline autoinjectors, and many who do receive them either do not know how to properly use the device or fail to carry it with them at all times.

Injured workers and bystanders often suffer oily wounds in accidents that must be cleaned prior to surgery.

New research suggests a mathematical algorithm can predict the onset of seizures in epilepsy patients up to 20 minutes in advance.

Just weeks after Australian researchers published data suggesting that testosterone replacement therapy does not ameliorate type 2 diabetes among hypogonadal men, a team of American researchers has unveiled a second study that suggests just the opposite.

The expanded use of biofeedback can provide multiple benefits for patients who report issues ranging from headaches to neck pain and muscle tension.

Failing to produce physiologically appropriate concentrations of testosterone and/or normal amounts of sperm can affect men in profound ways, depending on the causes and scope of their condition.

Patients who experience a head injury have an increased risk of receiving a subsequent diagnosis for a psychiatric disorder.

Although selective beta-blockers are generally better tolerated in asthma patients, a study published in Chest found the treatments are not without risk.

Researchers have identified a compound that reduces the levels of a key enzyme that regulates activity in pain receptors, pointing the way to new therapies for treating some forms of back pain, shingles, and other types of chronic neuropathic pain.