Internal Medicine

The selective topical PDE4 inhibitor demonstrated rapid improvements in IGA and EASI scores and high tolerability in pediatric populations.

Patients with IBD, rheumatoid arthritis, and psoriasis are commonly treated using biologic agents such as infliximab, tofacitinib, and ustekinumab.

On the latest Derm Discussions, Brett King, MD, PhD, joins Brad Glick, DO, to discuss the potential of the JAK inhibitor class for dermatology.

Exenatide extended-release represents the first regulatory approval for a once-weekly glucagon-like peptide-1 receptor agonist (GLP-1 RA) for pediatric patients with type 2 diabetes.

Males and patients with higher disease severity were more likely to attend program sessions.

More research is needed to understand the pathogenesis underlying this association.

While investigators did not meet their primary endpoint in the study, results in former smokers within the trial were promising and prompted further research on the subgroup.

The FDA will also not meet the PDUFA date for tofacitinib for the treatment of active ankylosing spondylitis.

Gastrointestinal infections were the most common serious infections associated with biologics, according to a cohort analysis.

The rare liver disease can often lead to liver failure.

A study notes that irradiation did not impact transfusion requirements or relevant laboratory values among patients receiving chronic blood transfusions.

More randomized controlled trials are needed to assess their long-term effectiveness, safety, and effects on health-related quality of life.

In a single-center study, no patients were screened annually for HIV and HCV.

The treatment met all 5 primary efficacy endpoints as part of the ASCEND program.

This patient group was at an increased risk for future exposure to systemic corticosteroids and anti-TNF biologics.

The FDA Cardiovascular and Renal Drugs Advisory Committee cited concerns over an increase in thrombotic events.

A new statement from the AHA and American Stroke Association stressed the need to address gaps in care that may lead to high risk of stroke recurrence.

The new kinoid vaccine has shown positive results in mice with human proteins, and the France-based team remain optimistic of human trials in the future.

Patients with glucocorticoid-refractory or -dependent chronic GVHD are more likely to experience complete or partial response with the JAK inhibitor than with control therapies.

A 12-week trial found implementing a dietary approach using a low-fat, vegan diet could help reduce the incidence of moderate-to-severe hot flashes in postmenopausal women.

Less than half of affected patients (42.86%) indicated previous history of conjunctivitis prior to initiating dupilumab treatment.

Biologic use was not associated with an increased risk of hepatitis B virus flares.

Metabolomic and preclinical studies have indicated that branched-chain amino acids may protect against neurodegenerative diseases.

Researchers in the UK recommend early detection and treatment of food allergy and sensitization to avoid complications in adulthood.

While the nerve disease is not life threatening, patients may experience considerable poor quality of life and emotional distress.

Research on the effect of methotrexate and other immunosuppressants in regard to the COVID-19 vaccine are encouraging yet unfinished.

An analysis of data from the Framingham Heart Study Offspring Cohort by investigators at the USDA Human Nutrition Research Center on Aging suggests greater consumption of whole grains was associated with a more preferable cardiometabolic risk profile than lesser consumption or consumption of refined grains.

A new report sheds light on the gaps in knowledge and research surrounding the reproductive health of girls and women with sickle cell disease.

A study from the Annual Congress of the European Association of Urology suggests undergoing testosterone therapy could improve cardiovascular health and reduce risk of adverse events in men with hypogonadism.

Retinal laser photocoagulation may be performed by a specialist from a distance using telemedicine platforms.